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MiRNA-221 from tissue may predict the prognosis of patients with osteosarcoma
This study was aimed to investigate the relationship between miR-221 expression and prognosis in patients with osteosarcoma. miR-221 expression in 69 osteosarcoma specimens and corresponding noncancer tissues were characterized by quantitative reverse transcription polymerase chain reaction. The ass...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wolters Kluwer Health
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086526/ https://www.ncbi.nlm.nih.gov/pubmed/30024497 http://dx.doi.org/10.1097/MD.0000000000011100 |
| Sumario: | This study was aimed to investigate the relationship between miR-221 expression and prognosis in patients with osteosarcoma. miR-221 expression in 69 osteosarcoma specimens and corresponding noncancer tissues were characterized by quantitative reverse transcription polymerase chain reaction. The associations of miR-221 expression with clinicopathologic factors and prognosis in patients with osteosarcoma were statistically analyzed. miR-221 expression in patients with osteosarcoma was significantly higher than in the corresponding noncancer tissues (P < .01). miR-221 overexpression was significantly associated with tumor stage, metastatic status, and response to chemotherapy pretreatment. Cox regression analysis revealed that miR-221expression, metastasis, and response to chemotherapy were independent prognostic indicators for osteosarcoma. miR-221 upregulation may predict clinical outcomes in patients with osteosarcoma. |
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