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Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients

BACKGROUND AND OBJECTIVES: Immune system–related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and po...

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Autores principales: Arababadi, Mohammad Kazemi, Mosavi, Reza, Ravari, Ali, Teimori, Hossein, Hassanshahi, Gholamhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086643/
https://www.ncbi.nlm.nih.gov/pubmed/22366824
http://dx.doi.org/10.5144/0256-4947.2012.127
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author Arababadi, Mohammad Kazemi
Mosavi, Reza
Ravari, Ali
Teimori, Hossein
Hassanshahi, Gholamhossein
author_facet Arababadi, Mohammad Kazemi
Mosavi, Reza
Ravari, Ali
Teimori, Hossein
Hassanshahi, Gholamhossein
author_sort Arababadi, Mohammad Kazemi
collection PubMed
description BACKGROUND AND OBJECTIVES: Immune system–related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4. DESIGN AND SETTING: A descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010. PATIENTS AND METHODS: Blood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study. RESULTS: We observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P<.001). CONCLUSIONS: We conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS.
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spelling pubmed-60866432018-09-21 Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients Arababadi, Mohammad Kazemi Mosavi, Reza Ravari, Ali Teimori, Hossein Hassanshahi, Gholamhossein Ann Saudi Med Original Article BACKGROUND AND OBJECTIVES: Immune system–related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4. DESIGN AND SETTING: A descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010. PATIENTS AND METHODS: Blood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study. RESULTS: We observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P<.001). CONCLUSIONS: We conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS. King Faisal Specialist Hospital and Research Centre 2012 /pmc/articles/PMC6086643/ /pubmed/22366824 http://dx.doi.org/10.5144/0256-4947.2012.127 Text en Copyright © 2012, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Arababadi, Mohammad Kazemi
Mosavi, Reza
Ravari, Ali
Teimori, Hossein
Hassanshahi, Gholamhossein
Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients
title Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients
title_full Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients
title_fullStr Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients
title_full_unstemmed Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients
title_short Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients
title_sort association of interleukin-4 polymorphisms with multiple sclerosis in southeastern iranian patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086643/
https://www.ncbi.nlm.nih.gov/pubmed/22366824
http://dx.doi.org/10.5144/0256-4947.2012.127
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