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A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans
During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input. How the brain reaches this state spontaneously is not known. General anesthesia provides a unique opportunity to examine how the human brain recovers its fun...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086660/ https://www.ncbi.nlm.nih.gov/pubmed/30095069 http://dx.doi.org/10.7554/eLife.33250 |
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author | Lewis, Laura D Piantoni, Giovanni Peterfreund, Robert A Eskandar, Emad N Harrell, Priscilla Grace Akeju, Oluwaseun Aglio, Linda S Cash, Sydney S Brown, Emery N Mukamel, Eran A Purdon, Patrick L |
author_facet | Lewis, Laura D Piantoni, Giovanni Peterfreund, Robert A Eskandar, Emad N Harrell, Priscilla Grace Akeju, Oluwaseun Aglio, Linda S Cash, Sydney S Brown, Emery N Mukamel, Eran A Purdon, Patrick L |
author_sort | Lewis, Laura D |
collection | PubMed |
description | During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input. How the brain reaches this state spontaneously is not known. General anesthesia provides a unique opportunity to examine how the human brain recovers its functional capabilities after profound unconsciousness. We used intracranial electrocorticography and scalp EEG in humans to track neural dynamics during emergence from propofol general anesthesia. We identify a distinct transient brain state that occurs immediately prior to recovery of behavioral responsiveness. This state is characterized by large, spatially distributed, slow sensory-evoked potentials that resemble the K-complexes that are hallmarks of stage two sleep. However, the ongoing spontaneous dynamics in this transitional state differ from sleep. These results identify an asymmetry in the neurophysiology of induction and emergence, as the emerging brain can enter a state with a sleep-like sensory blockade before regaining responsivity to arousing stimuli. |
format | Online Article Text |
id | pubmed-6086660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60866602018-08-13 A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans Lewis, Laura D Piantoni, Giovanni Peterfreund, Robert A Eskandar, Emad N Harrell, Priscilla Grace Akeju, Oluwaseun Aglio, Linda S Cash, Sydney S Brown, Emery N Mukamel, Eran A Purdon, Patrick L eLife Neuroscience During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input. How the brain reaches this state spontaneously is not known. General anesthesia provides a unique opportunity to examine how the human brain recovers its functional capabilities after profound unconsciousness. We used intracranial electrocorticography and scalp EEG in humans to track neural dynamics during emergence from propofol general anesthesia. We identify a distinct transient brain state that occurs immediately prior to recovery of behavioral responsiveness. This state is characterized by large, spatially distributed, slow sensory-evoked potentials that resemble the K-complexes that are hallmarks of stage two sleep. However, the ongoing spontaneous dynamics in this transitional state differ from sleep. These results identify an asymmetry in the neurophysiology of induction and emergence, as the emerging brain can enter a state with a sleep-like sensory blockade before regaining responsivity to arousing stimuli. eLife Sciences Publications, Ltd 2018-08-10 /pmc/articles/PMC6086660/ /pubmed/30095069 http://dx.doi.org/10.7554/eLife.33250 Text en © 2018, Lewis et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Lewis, Laura D Piantoni, Giovanni Peterfreund, Robert A Eskandar, Emad N Harrell, Priscilla Grace Akeju, Oluwaseun Aglio, Linda S Cash, Sydney S Brown, Emery N Mukamel, Eran A Purdon, Patrick L A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans |
title | A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans |
title_full | A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans |
title_fullStr | A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans |
title_full_unstemmed | A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans |
title_short | A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans |
title_sort | transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086660/ https://www.ncbi.nlm.nih.gov/pubmed/30095069 http://dx.doi.org/10.7554/eLife.33250 |
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