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Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
Cerebellar ataxias are severe neurodegenerative disorders with an early onset and progressive and inexorable course of the disease. Here, we report a single point mutation in the gene encoding Elongator complex subunit 6 causing Purkinje neuron degeneration and an ataxia-like phenotype in the mutant...
Autores principales: | Kojic, Marija, Gaik, Monika, Kiska, Bence, Salerno-Kochan, Anna, Hunt, Sarah, Tedoldi, Angelo, Mureev, Sergey, Jones, Alun, Whittle, Belinda, Genovesi, Laura A., Adolphe, Christelle, Brown, Darren L., Stow, Jennifer L., Alexandrov, Kirill, Sah, Pankaj, Glatt, Sebastian, Wainwright, Brandon J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086839/ https://www.ncbi.nlm.nih.gov/pubmed/30097576 http://dx.doi.org/10.1038/s41467-018-05765-6 |
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