Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection

The human liver chimeric mouse with primary human hepatocytes (PHHs) engraftment has been demonstrated to be a useful animal model to study hepatitis B virus (HBV) pathogenesis and evaluate anti-HBV drugs. However, the disadvantages of using PHHs include the inability for cellular expansion in vitro...

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Detalles Bibliográficos
Autores principales: Yuan, Lunzhi, Liu, Xuan, Zhang, Liang, Zhang, Yali, Chen, Yao, Li, Xiaoling, Wu, Kun, Cao, Jiali, Hou, Wangheng, Que, Yuqiong, Zhang, Jun, Zhu, Hua, Yuan, Quan, Tang, Qiyi, Cheng, Tong, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086841/
https://www.ncbi.nlm.nih.gov/pubmed/30097574
http://dx.doi.org/10.1038/s41426-018-0143-9

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