Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV‐infected H441 cells showed increased mRNA expression of connective t...

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Detalles Bibliográficos
Autores principales: Kunzmann, Steffen, Krempl, Christine, Seidenspinner, Silvia, Glaser, Kirsten, Speer, Christian P., Fehrholz, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086851/
https://www.ncbi.nlm.nih.gov/pubmed/29660819
http://dx.doi.org/10.1111/irv.12561
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author Kunzmann, Steffen
Krempl, Christine
Seidenspinner, Silvia
Glaser, Kirsten
Speer, Christian P.
Fehrholz, Markus
author_facet Kunzmann, Steffen
Krempl, Christine
Seidenspinner, Silvia
Glaser, Kirsten
Speer, Christian P.
Fehrholz, Markus
author_sort Kunzmann, Steffen
collection PubMed
description Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV‐infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV‐mediated increase in CTGF mRNA. RSV may be involved in airway remodeling processes by increasing CTGF mRNA expression. Caffeine might abrogate these negative effects and thereby help to restore lung homeostasis.
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spelling pubmed-60868512018-09-01 Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells Kunzmann, Steffen Krempl, Christine Seidenspinner, Silvia Glaser, Kirsten Speer, Christian P. Fehrholz, Markus Influenza Other Respir Viruses Short Article Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV‐infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV‐mediated increase in CTGF mRNA. RSV may be involved in airway remodeling processes by increasing CTGF mRNA expression. Caffeine might abrogate these negative effects and thereby help to restore lung homeostasis. John Wiley and Sons Inc. 2018-05-22 2018-09 /pmc/articles/PMC6086851/ /pubmed/29660819 http://dx.doi.org/10.1111/irv.12561 Text en © 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Article
Kunzmann, Steffen
Krempl, Christine
Seidenspinner, Silvia
Glaser, Kirsten
Speer, Christian P.
Fehrholz, Markus
Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
title Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
title_full Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
title_fullStr Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
title_full_unstemmed Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
title_short Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
title_sort increase in ctgf mrna expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
topic Short Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086851/
https://www.ncbi.nlm.nih.gov/pubmed/29660819
http://dx.doi.org/10.1111/irv.12561
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