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Cortical signatures of wakeful somatosensory processing
Sensory inputs carry critical information for the survival of an organism. In mice, tactile information conveyed by the whiskers is of high behavioural relevance, and is broadcasted across cortical areas beyond the primary somatosensory cortex. Mesoscopic voltage sensitive dye imaging (VSDI) of cort...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086870/ https://www.ncbi.nlm.nih.gov/pubmed/30097603 http://dx.doi.org/10.1038/s41598-018-30422-9 |
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author | Song, Chenchen Piscopo, Denise M. Niell, Cristopher M. Knöpfel, Thomas |
author_facet | Song, Chenchen Piscopo, Denise M. Niell, Cristopher M. Knöpfel, Thomas |
author_sort | Song, Chenchen |
collection | PubMed |
description | Sensory inputs carry critical information for the survival of an organism. In mice, tactile information conveyed by the whiskers is of high behavioural relevance, and is broadcasted across cortical areas beyond the primary somatosensory cortex. Mesoscopic voltage sensitive dye imaging (VSDI) of cortical population response to whisker stimulations has shown that seemingly ‘simple’ sensory stimuli can have extended impact on cortical circuit dynamics. Here we took advantage of genetically encoded voltage indicators (GEVIs) that allow for cell type-specific monitoring of population voltage dynamics in a chronic dual-hemisphere transcranial windowed mouse preparation to directly compare the cortex-wide broadcasting of sensory information in wakening (lightly anesthetized to sedated) and awake mice. Somatosensory-evoked cortex-wide dynamics is altered across brain states, with anatomically sequential hyperpolarising activity observed in the awake cortex. GEVI imaging revealed cortical activity maps with increased specificity, high spatial coverage, and at the timescale of cortical information processing. |
format | Online Article Text |
id | pubmed-6086870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60868702018-08-16 Cortical signatures of wakeful somatosensory processing Song, Chenchen Piscopo, Denise M. Niell, Cristopher M. Knöpfel, Thomas Sci Rep Article Sensory inputs carry critical information for the survival of an organism. In mice, tactile information conveyed by the whiskers is of high behavioural relevance, and is broadcasted across cortical areas beyond the primary somatosensory cortex. Mesoscopic voltage sensitive dye imaging (VSDI) of cortical population response to whisker stimulations has shown that seemingly ‘simple’ sensory stimuli can have extended impact on cortical circuit dynamics. Here we took advantage of genetically encoded voltage indicators (GEVIs) that allow for cell type-specific monitoring of population voltage dynamics in a chronic dual-hemisphere transcranial windowed mouse preparation to directly compare the cortex-wide broadcasting of sensory information in wakening (lightly anesthetized to sedated) and awake mice. Somatosensory-evoked cortex-wide dynamics is altered across brain states, with anatomically sequential hyperpolarising activity observed in the awake cortex. GEVI imaging revealed cortical activity maps with increased specificity, high spatial coverage, and at the timescale of cortical information processing. Nature Publishing Group UK 2018-08-10 /pmc/articles/PMC6086870/ /pubmed/30097603 http://dx.doi.org/10.1038/s41598-018-30422-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Song, Chenchen Piscopo, Denise M. Niell, Cristopher M. Knöpfel, Thomas Cortical signatures of wakeful somatosensory processing |
title | Cortical signatures of wakeful somatosensory processing |
title_full | Cortical signatures of wakeful somatosensory processing |
title_fullStr | Cortical signatures of wakeful somatosensory processing |
title_full_unstemmed | Cortical signatures of wakeful somatosensory processing |
title_short | Cortical signatures of wakeful somatosensory processing |
title_sort | cortical signatures of wakeful somatosensory processing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086870/ https://www.ncbi.nlm.nih.gov/pubmed/30097603 http://dx.doi.org/10.1038/s41598-018-30422-9 |
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