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Cortical signatures of wakeful somatosensory processing

Sensory inputs carry critical information for the survival of an organism. In mice, tactile information conveyed by the whiskers is of high behavioural relevance, and is broadcasted across cortical areas beyond the primary somatosensory cortex. Mesoscopic voltage sensitive dye imaging (VSDI) of cort...

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Autores principales: Song, Chenchen, Piscopo, Denise M., Niell, Cristopher M., Knöpfel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086870/
https://www.ncbi.nlm.nih.gov/pubmed/30097603
http://dx.doi.org/10.1038/s41598-018-30422-9
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author Song, Chenchen
Piscopo, Denise M.
Niell, Cristopher M.
Knöpfel, Thomas
author_facet Song, Chenchen
Piscopo, Denise M.
Niell, Cristopher M.
Knöpfel, Thomas
author_sort Song, Chenchen
collection PubMed
description Sensory inputs carry critical information for the survival of an organism. In mice, tactile information conveyed by the whiskers is of high behavioural relevance, and is broadcasted across cortical areas beyond the primary somatosensory cortex. Mesoscopic voltage sensitive dye imaging (VSDI) of cortical population response to whisker stimulations has shown that seemingly ‘simple’ sensory stimuli can have extended impact on cortical circuit dynamics. Here we took advantage of genetically encoded voltage indicators (GEVIs) that allow for cell type-specific monitoring of population voltage dynamics in a chronic dual-hemisphere transcranial windowed mouse preparation to directly compare the cortex-wide broadcasting of sensory information in wakening (lightly anesthetized to sedated) and awake mice. Somatosensory-evoked cortex-wide dynamics is altered across brain states, with anatomically sequential hyperpolarising activity observed in the awake cortex. GEVI imaging revealed cortical activity maps with increased specificity, high spatial coverage, and at the timescale of cortical information processing.
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spelling pubmed-60868702018-08-16 Cortical signatures of wakeful somatosensory processing Song, Chenchen Piscopo, Denise M. Niell, Cristopher M. Knöpfel, Thomas Sci Rep Article Sensory inputs carry critical information for the survival of an organism. In mice, tactile information conveyed by the whiskers is of high behavioural relevance, and is broadcasted across cortical areas beyond the primary somatosensory cortex. Mesoscopic voltage sensitive dye imaging (VSDI) of cortical population response to whisker stimulations has shown that seemingly ‘simple’ sensory stimuli can have extended impact on cortical circuit dynamics. Here we took advantage of genetically encoded voltage indicators (GEVIs) that allow for cell type-specific monitoring of population voltage dynamics in a chronic dual-hemisphere transcranial windowed mouse preparation to directly compare the cortex-wide broadcasting of sensory information in wakening (lightly anesthetized to sedated) and awake mice. Somatosensory-evoked cortex-wide dynamics is altered across brain states, with anatomically sequential hyperpolarising activity observed in the awake cortex. GEVI imaging revealed cortical activity maps with increased specificity, high spatial coverage, and at the timescale of cortical information processing. Nature Publishing Group UK 2018-08-10 /pmc/articles/PMC6086870/ /pubmed/30097603 http://dx.doi.org/10.1038/s41598-018-30422-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Song, Chenchen
Piscopo, Denise M.
Niell, Cristopher M.
Knöpfel, Thomas
Cortical signatures of wakeful somatosensory processing
title Cortical signatures of wakeful somatosensory processing
title_full Cortical signatures of wakeful somatosensory processing
title_fullStr Cortical signatures of wakeful somatosensory processing
title_full_unstemmed Cortical signatures of wakeful somatosensory processing
title_short Cortical signatures of wakeful somatosensory processing
title_sort cortical signatures of wakeful somatosensory processing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086870/
https://www.ncbi.nlm.nih.gov/pubmed/30097603
http://dx.doi.org/10.1038/s41598-018-30422-9
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