A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

The biological determinants of sensitivity and resistance to immune checkpoint blockers are not completely understood. To elucidate the role of intratumoral T-cells and their association with the tumor genomic landscape, we perform paired whole exome DNA sequencing and multiplexed quantitative immun...

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Detalles Bibliográficos
Autores principales: Gettinger, S. N., Choi, J., Mani, N., Sanmamed, M. F., Datar, I., Sowell, Ryan, Du, Victor Y., Kaftan, E., Goldberg, S., Dong, W., Zelterman, D., Politi, K., Kavathas, P., Kaech, S., Yu, X., Zhao, H., Schlessinger, J., Lifton, R., Rimm, D. L., Chen, L., Herbst, R. S., Schalper, K. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086912/
https://www.ncbi.nlm.nih.gov/pubmed/30097571
http://dx.doi.org/10.1038/s41467-018-05032-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086912/
https://www.ncbi.nlm.nih.gov/pubmed/30097571
http://dx.doi.org/10.1038/s41467-018-05032-8

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