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Role of hypoxia-induced exosomes in tumor biology
PURPOSE: Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. METHODS: The relevant publications were retrieved from PubMed using keywords s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087002/ https://www.ncbi.nlm.nih.gov/pubmed/30098600 http://dx.doi.org/10.1186/s12943-018-0869-y |
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author | Shao, Chuchu Yang, Fengming Miao, Suyu Liu, Weitao Wang, Chaoshan Shu, Yongqian Shen, Hua |
author_facet | Shao, Chuchu Yang, Fengming Miao, Suyu Liu, Weitao Wang, Chaoshan Shu, Yongqian Shen, Hua |
author_sort | Shao, Chuchu |
collection | PubMed |
description | PURPOSE: Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. METHODS: The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms. RESULTS: Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system. CONCLUSIONS: These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies. |
format | Online Article Text |
id | pubmed-6087002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60870022018-08-20 Role of hypoxia-induced exosomes in tumor biology Shao, Chuchu Yang, Fengming Miao, Suyu Liu, Weitao Wang, Chaoshan Shu, Yongqian Shen, Hua Mol Cancer Review PURPOSE: Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. METHODS: The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms. RESULTS: Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system. CONCLUSIONS: These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies. BioMed Central 2018-08-11 /pmc/articles/PMC6087002/ /pubmed/30098600 http://dx.doi.org/10.1186/s12943-018-0869-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Shao, Chuchu Yang, Fengming Miao, Suyu Liu, Weitao Wang, Chaoshan Shu, Yongqian Shen, Hua Role of hypoxia-induced exosomes in tumor biology |
title | Role of hypoxia-induced exosomes in tumor biology |
title_full | Role of hypoxia-induced exosomes in tumor biology |
title_fullStr | Role of hypoxia-induced exosomes in tumor biology |
title_full_unstemmed | Role of hypoxia-induced exosomes in tumor biology |
title_short | Role of hypoxia-induced exosomes in tumor biology |
title_sort | role of hypoxia-induced exosomes in tumor biology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087002/ https://www.ncbi.nlm.nih.gov/pubmed/30098600 http://dx.doi.org/10.1186/s12943-018-0869-y |
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