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Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients

BACKGROUND: Patients with systemic lupus erythematosus (SLE), especially with lupus nephritis (LN), undergo vascular damage and repair during the course of the disease. Since the recently identified angiogenic T cells (Tang) are involved in endothelial repair coupled with endothelial progenitor cell...

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Autores principales: Zhao, Peng, Miao, Jinlin, Zhang, Kui, Lv, Minghua, Han, Qing, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087034/
https://www.ncbi.nlm.nih.gov/pubmed/30072685
http://dx.doi.org/10.12659/MSM.908406
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author Zhao, Peng
Miao, Jinlin
Zhang, Kui
Lv, Minghua
Han, Qing
Zhu, Ping
author_facet Zhao, Peng
Miao, Jinlin
Zhang, Kui
Lv, Minghua
Han, Qing
Zhu, Ping
author_sort Zhao, Peng
collection PubMed
description BACKGROUND: Patients with systemic lupus erythematosus (SLE), especially with lupus nephritis (LN), undergo vascular damage and repair during the course of the disease. Since the recently identified angiogenic T cells (Tang) are involved in endothelial repair coupled with endothelial progenitor cells (EPCs), this study investigated the circulating Tang cells in LN patients and their potential correlations with disease features. MATERIAL/METHODS: Circulating Tang cells and EPCs were assessed by flow cytometry in peripheral blood samples from 67 SLE patients; of these, 32 had LN and 30 were matched healthy controls (HCs). The plasma levels of interleukin IL-17, IL-8, and vascular endothelial growth factor (VEGF) were quantified by immunoassays. RESULTS: The percentage of circulating Tang cells in LN patients was significantly increased as compared to the non-LN patients and HCs, and they were positively correlated with the level of EPC and VEGF. Additionally, circulating Tang cell percentages were positively correlated with the extent of proteinuria in LN patients. CONCLUSIONS: The increased levels of circulating Tang cells in LN patients might play a role in the balance of endothelium dysfunction in these patients.
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spelling pubmed-60870342018-08-16 Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients Zhao, Peng Miao, Jinlin Zhang, Kui Lv, Minghua Han, Qing Zhu, Ping Med Sci Monit Clinical Research BACKGROUND: Patients with systemic lupus erythematosus (SLE), especially with lupus nephritis (LN), undergo vascular damage and repair during the course of the disease. Since the recently identified angiogenic T cells (Tang) are involved in endothelial repair coupled with endothelial progenitor cells (EPCs), this study investigated the circulating Tang cells in LN patients and their potential correlations with disease features. MATERIAL/METHODS: Circulating Tang cells and EPCs were assessed by flow cytometry in peripheral blood samples from 67 SLE patients; of these, 32 had LN and 30 were matched healthy controls (HCs). The plasma levels of interleukin IL-17, IL-8, and vascular endothelial growth factor (VEGF) were quantified by immunoassays. RESULTS: The percentage of circulating Tang cells in LN patients was significantly increased as compared to the non-LN patients and HCs, and they were positively correlated with the level of EPC and VEGF. Additionally, circulating Tang cell percentages were positively correlated with the extent of proteinuria in LN patients. CONCLUSIONS: The increased levels of circulating Tang cells in LN patients might play a role in the balance of endothelium dysfunction in these patients. International Scientific Literature, Inc. 2018-08-03 /pmc/articles/PMC6087034/ /pubmed/30072685 http://dx.doi.org/10.12659/MSM.908406 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Zhao, Peng
Miao, Jinlin
Zhang, Kui
Lv, Minghua
Han, Qing
Zhu, Ping
Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients
title Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients
title_full Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients
title_fullStr Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients
title_full_unstemmed Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients
title_short Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients
title_sort circulating angiogenic t cells are increased in lupus nephritis patients
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087034/
https://www.ncbi.nlm.nih.gov/pubmed/30072685
http://dx.doi.org/10.12659/MSM.908406
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