Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment

The human NDR family kinases control diverse aspects of cell growth, and are regulated through phosphorylation and association with scaffolds such as MOB1. Here, we report the crystal structure of the human NDR1 kinase domain in its non-phosphorylated state, revealing a fully resolved atypically lon...

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Detalles Bibliográficos
Autores principales: Xiong, Shawn, Lorenzen, Kristina, Couzens, Amber L., Templeton, Catherine M., Rajendran, Dushyandi, Mao, Daniel Y.L., Juang, Yu-Chi, Chiovitti, David, Kurinov, Igor, Guettler, Sebastian, Gingras, Anne-Claude, Sicheri, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087429/
https://www.ncbi.nlm.nih.gov/pubmed/29983373
http://dx.doi.org/10.1016/j.str.2018.05.014

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