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Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking

BACKGROUND: Smoking is a known predisposing factor to exacerbations in CF patients. But the effects of second-hand tobacco smoking are not yet clear. Hence, this study determined the clinical and spirometric presentations and urinary cotinine levels among cystic fibrosis patients over seven years of...

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Autores principales: Hassanzad, Maryam, Eslampanah, Shabnam, Modaresi, Mohammadreza, Tashayoie-Nejad, Sabereh, Velayati, Ali Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087526/
https://www.ncbi.nlm.nih.gov/pubmed/30116277
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author Hassanzad, Maryam
Eslampanah, Shabnam
Modaresi, Mohammadreza
Tashayoie-Nejad, Sabereh
Velayati, Ali Akbar
author_facet Hassanzad, Maryam
Eslampanah, Shabnam
Modaresi, Mohammadreza
Tashayoie-Nejad, Sabereh
Velayati, Ali Akbar
author_sort Hassanzad, Maryam
collection PubMed
description BACKGROUND: Smoking is a known predisposing factor to exacerbations in CF patients. But the effects of second-hand tobacco smoking are not yet clear. Hence, this study determined the clinical and spirometric presentations and urinary cotinine levels among cystic fibrosis patients over seven years of age in relation to their parent’s smoking history. MATERIALS AND METHODS: In this cross-sectional comparative study, 58 consecutive cystic fibrosis patients older than seven years of age were enrolled. These patients were divided into two equal groups: those with second-hand tobacco smoking and those without. Pulmonary function tests and hospital admission rates were compared across the groups. RESULTS: The mean hospital admission times were 5.1±2.4 in the group with passive smoking, and 2.6±1.3 times in the group without (P<0.001). The cotinine level was reversely correlated to time interval passed from previous admissions (P=0.001, r=−0.432) in passive smokers and (P=0.021, r=0.314) in non-passive smokers. In the analysis of FEV1 with urine, there was a significant but negative relation between FEV1 and cotinine (P= 0.002). Besides, in the analysis of FE 25–75 and urine cotinine, there was also a significant and negative relationship (P=0.001). CONCLUSION: From our findings, we conclude that pulmonary function tests and hospital admission rate in patients with cystic fibrosis are associated with urinary cotinine level and household second-hand tobacco smoking.
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spelling pubmed-60875262018-08-16 Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking Hassanzad, Maryam Eslampanah, Shabnam Modaresi, Mohammadreza Tashayoie-Nejad, Sabereh Velayati, Ali Akbar Tanaffos Original Article BACKGROUND: Smoking is a known predisposing factor to exacerbations in CF patients. But the effects of second-hand tobacco smoking are not yet clear. Hence, this study determined the clinical and spirometric presentations and urinary cotinine levels among cystic fibrosis patients over seven years of age in relation to their parent’s smoking history. MATERIALS AND METHODS: In this cross-sectional comparative study, 58 consecutive cystic fibrosis patients older than seven years of age were enrolled. These patients were divided into two equal groups: those with second-hand tobacco smoking and those without. Pulmonary function tests and hospital admission rates were compared across the groups. RESULTS: The mean hospital admission times were 5.1±2.4 in the group with passive smoking, and 2.6±1.3 times in the group without (P<0.001). The cotinine level was reversely correlated to time interval passed from previous admissions (P=0.001, r=−0.432) in passive smokers and (P=0.021, r=0.314) in non-passive smokers. In the analysis of FEV1 with urine, there was a significant but negative relation between FEV1 and cotinine (P= 0.002). Besides, in the analysis of FE 25–75 and urine cotinine, there was also a significant and negative relationship (P=0.001). CONCLUSION: From our findings, we conclude that pulmonary function tests and hospital admission rate in patients with cystic fibrosis are associated with urinary cotinine level and household second-hand tobacco smoking. National Research Institute of Tuberculosis and Lung Disease 2018-01 /pmc/articles/PMC6087526/ /pubmed/30116277 Text en Copyright© 2018 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hassanzad, Maryam
Eslampanah, Shabnam
Modaresi, Mohammadreza
Tashayoie-Nejad, Sabereh
Velayati, Ali Akbar
Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking
title Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking
title_full Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking
title_fullStr Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking
title_full_unstemmed Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking
title_short Pulmonary Function and Hospital Admission in Patients with Cystic Fibrosis Based on Household Second-Hand Smoking
title_sort pulmonary function and hospital admission in patients with cystic fibrosis based on household second-hand smoking
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087526/
https://www.ncbi.nlm.nih.gov/pubmed/30116277
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