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A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts

BACKGROUND AND OBJECTIVE: Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the...

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Autores principales: Brito-Mendoza, Luisana, Bologna-Molina, Ronell, Irigoyen-Camacho, María Esther, Martinez, Guillermo, Sánchez-Romero, Celeste, Mosqueda-Taylor, Adalberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087607/
https://www.ncbi.nlm.nih.gov/pubmed/30151060
http://dx.doi.org/10.1155/2018/7048531
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author Brito-Mendoza, Luisana
Bologna-Molina, Ronell
Irigoyen-Camacho, María Esther
Martinez, Guillermo
Sánchez-Romero, Celeste
Mosqueda-Taylor, Adalberto
author_facet Brito-Mendoza, Luisana
Bologna-Molina, Ronell
Irigoyen-Camacho, María Esther
Martinez, Guillermo
Sánchez-Romero, Celeste
Mosqueda-Taylor, Adalberto
author_sort Brito-Mendoza, Luisana
collection PubMed
description BACKGROUND AND OBJECTIVE: Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, CD138, and the molecular triad RANK, RANKL, and OPG in odontogenic keratocysts (OKC), unicystic ameloblastomas (UA), and dentigerous cysts (DC). METHODS: Immunohistochemistry for Ki-67, CD138, RANK, RANKL, and OPG was performed in 58 odontogenic cystic lesions (22 OKC, 17 DC, and 19 UA). RESULTS: A higher expression of Ki-67 was identified in OKC as compared to UA (p < 0.0001). UA exhibited a greater loss of CD138 expression versus OKCs (p > 0.0034). RANKL was expressed higher in the epithelium (p = 0.0002) and in the stroma (p = 0.0004) of UA. DC had a lower expression of these markers. CONCLUSION: Higher RANKL expression together with the reduction on CD138 expression in UA could be linked to a greater invasive and destructive potential, while the increased proliferation rate observed in OKC could be related to its continuous intrabony growth. The expansion of DC does not seem to be related to such factors, justifying the different therapeutic approaches proposed for each of these entities.
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spelling pubmed-60876072018-08-27 A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts Brito-Mendoza, Luisana Bologna-Molina, Ronell Irigoyen-Camacho, María Esther Martinez, Guillermo Sánchez-Romero, Celeste Mosqueda-Taylor, Adalberto Dis Markers Research Article BACKGROUND AND OBJECTIVE: Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, CD138, and the molecular triad RANK, RANKL, and OPG in odontogenic keratocysts (OKC), unicystic ameloblastomas (UA), and dentigerous cysts (DC). METHODS: Immunohistochemistry for Ki-67, CD138, RANK, RANKL, and OPG was performed in 58 odontogenic cystic lesions (22 OKC, 17 DC, and 19 UA). RESULTS: A higher expression of Ki-67 was identified in OKC as compared to UA (p < 0.0001). UA exhibited a greater loss of CD138 expression versus OKCs (p > 0.0034). RANKL was expressed higher in the epithelium (p = 0.0002) and in the stroma (p = 0.0004) of UA. DC had a lower expression of these markers. CONCLUSION: Higher RANKL expression together with the reduction on CD138 expression in UA could be linked to a greater invasive and destructive potential, while the increased proliferation rate observed in OKC could be related to its continuous intrabony growth. The expansion of DC does not seem to be related to such factors, justifying the different therapeutic approaches proposed for each of these entities. Hindawi 2018-07-29 /pmc/articles/PMC6087607/ /pubmed/30151060 http://dx.doi.org/10.1155/2018/7048531 Text en Copyright © 2018 Luisana Brito-Mendoza et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Brito-Mendoza, Luisana
Bologna-Molina, Ronell
Irigoyen-Camacho, María Esther
Martinez, Guillermo
Sánchez-Romero, Celeste
Mosqueda-Taylor, Adalberto
A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
title A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
title_full A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
title_fullStr A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
title_full_unstemmed A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
title_short A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
title_sort comparison of ki67, syndecan-1 (cd138), and molecular rank, rankl, and opg triad expression in odontogenic keratocyts, unicystic ameloblastoma, and dentigerous cysts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087607/
https://www.ncbi.nlm.nih.gov/pubmed/30151060
http://dx.doi.org/10.1155/2018/7048531
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