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Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and survival in conjunction with other core cancer pathways. Nuclear phosphorylated STAT3 and STAT5 regulate cell-type-specific transcription...
Autores principales: | Wingelhofer, Bettina, Neubauer, Heidi A., Valent, Peter, Han, Xiaonan, Constantinescu, Stefan N., Gunning, Patrick T., Müller, Mathias, Moriggl, Richard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087715/ https://www.ncbi.nlm.nih.gov/pubmed/29728695 http://dx.doi.org/10.1038/s41375-018-0117-x |
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