1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication

Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benz...

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Autores principales: Nikitenko, N. A., Gureeva, E. S., Ozerov, A. A., Tukhvatulin, A. I., Izhaeva, F. M., Prassolov, V. S., Deryabin, P. G., Novikov, M. S., Logunov, D. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087815/
https://www.ncbi.nlm.nih.gov/pubmed/30116616
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author Nikitenko, N. A.
Gureeva, E. S.
Ozerov, A. A.
Tukhvatulin, A. I.
Izhaeva, F. M.
Prassolov, V. S.
Deryabin, P. G.
Novikov, M. S.
Logunov, D. Y.
author_facet Nikitenko, N. A.
Gureeva, E. S.
Ozerov, A. A.
Tukhvatulin, A. I.
Izhaeva, F. M.
Prassolov, V. S.
Deryabin, P. G.
Novikov, M. S.
Logunov, D. Y.
author_sort Nikitenko, N. A.
collection PubMed
description Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.
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spelling pubmed-60878152018-08-16 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication Nikitenko, N. A. Gureeva, E. S. Ozerov, A. A. Tukhvatulin, A. I. Izhaeva, F. M. Prassolov, V. S. Deryabin, P. G. Novikov, M. S. Logunov, D. Y. Acta Naturae Research Article Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed. A.I. Gordeyev 2018 /pmc/articles/PMC6087815/ /pubmed/30116616 Text en Copyright ® 2018 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nikitenko, N. A.
Gureeva, E. S.
Ozerov, A. A.
Tukhvatulin, A. I.
Izhaeva, F. M.
Prassolov, V. S.
Deryabin, P. G.
Novikov, M. S.
Logunov, D. Y.
1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication
title 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication
title_full 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication
title_fullStr 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication
title_full_unstemmed 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication
title_short 1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues – Novel Inhibitors of Human Adenovirus Replication
title_sort 1-(4-phenoxybenzyl) 5-aminouracil derivatives and their analogues – novel inhibitors of human adenovirus replication
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087815/
https://www.ncbi.nlm.nih.gov/pubmed/30116616
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