Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI). Like most other complex traits, LDD is likely polygenic and influenced by both...

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Detalles Bibliográficos
Autores principales: Zhou, Xueya, Cheung, Ching-Lung, Karasugi, Tatsuki, Karppinen, Jaro, Samartzis, Dino, Hsu, Yi-Hsiang, Mak, Timothy Shin-Heng, Song, You-Qiang, Chiba, Kazuhiro, Kawaguchi, Yoshiharu, Li, Yan, Chan, Danny, Cheung, Kenneth Man-Chee, Ikegawa, Shiro, Cheah, Kathryn Song-Eng, Sham, Pak Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088183/
https://www.ncbi.nlm.nih.gov/pubmed/30127800
http://dx.doi.org/10.3389/fgene.2018.00267

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