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Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer
Surfactant protein D (SP-D) is a pattern recognition molecule belonging to the Collectin (collagen-containing C-type lectin) family that has pulmonary as well as extra-pulmonary existence. In the lungs, it is a well-established opsonin that can agglutinate a range of microbes, and enhance their clea...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088209/ https://www.ncbi.nlm.nih.gov/pubmed/30127783 http://dx.doi.org/10.3389/fimmu.2018.01748 |
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author | Mangogna, Alessandro Belmonte, Beatrice Agostinis, Chiara Ricci, Giuseppe Gulino, Alessandro Ferrara, Ines Zanconati, Fabrizio Tripodo, Claudio Romano, Federico Kishore, Uday Bulla, Roberta |
author_facet | Mangogna, Alessandro Belmonte, Beatrice Agostinis, Chiara Ricci, Giuseppe Gulino, Alessandro Ferrara, Ines Zanconati, Fabrizio Tripodo, Claudio Romano, Federico Kishore, Uday Bulla, Roberta |
author_sort | Mangogna, Alessandro |
collection | PubMed |
description | Surfactant protein D (SP-D) is a pattern recognition molecule belonging to the Collectin (collagen-containing C-type lectin) family that has pulmonary as well as extra-pulmonary existence. In the lungs, it is a well-established opsonin that can agglutinate a range of microbes, and enhance their clearance via phagocytosis and super-oxidative burst. It can interfere with allergen–IgE interaction and suppress basophil and mast cell activation. However, it is now becoming evident that SP-D is likely to be an innate immune surveillance molecule against tumor development. SP-D has been shown to induce apoptosis in sensitized eosinophils derived from allergic patients and a leukemic cell line via p53 pathway. Recently, SP-D has been shown to suppress lung cancer progression via interference with the epidermal growth factor signaling. In addition, a truncated form of recombinant human SP-D has been reported to induce apoptosis in pancreatic adenocarcinoma via Fas-mediated pathway in a p53-independent manner. To further establish a correlation between SP-D presence/levels and normal and cancer tissues, we performed a bioinformatics analysis, using Oncomine dataset and the survival analysis platforms Kaplan–Meier plotter, to assess if SP-D can serve as a potential prognostic marker for human lung cancer, in addition to human gastric, breast, and ovarian cancers. We also analyzed immunohistochemically the presence of SP-D in normal and tumor human tissues. We conclude that (1) in the lung, gastric, and breast cancers, there is a lower expression of SP-D than normal tissues; (2) in ovarian cancer, there is a higher expression of SP-D than normal tissue; and (3) in lung cancer, the presence of SP-D could be associated with a favorable prognosis. On the contrary, at non-pulmonary sites such as gastric, breast, and ovarian cancers, the presence of SP-D could be associated with unfavorable prognosis. Correlation between the levels of SP-D and overall survival requires further investigation. Our analysis involves a large number of dataset; therefore, any trend observed is reliable. Despite apparent complexity within the results, it is evident that cancer tissues that produce less levels of SP-D compared to their normal tissue counterparts are probably less susceptible to SP-D-mediated immune surveillance mechanisms via infiltrating immune cells. |
format | Online Article Text |
id | pubmed-6088209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60882092018-08-20 Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer Mangogna, Alessandro Belmonte, Beatrice Agostinis, Chiara Ricci, Giuseppe Gulino, Alessandro Ferrara, Ines Zanconati, Fabrizio Tripodo, Claudio Romano, Federico Kishore, Uday Bulla, Roberta Front Immunol Immunology Surfactant protein D (SP-D) is a pattern recognition molecule belonging to the Collectin (collagen-containing C-type lectin) family that has pulmonary as well as extra-pulmonary existence. In the lungs, it is a well-established opsonin that can agglutinate a range of microbes, and enhance their clearance via phagocytosis and super-oxidative burst. It can interfere with allergen–IgE interaction and suppress basophil and mast cell activation. However, it is now becoming evident that SP-D is likely to be an innate immune surveillance molecule against tumor development. SP-D has been shown to induce apoptosis in sensitized eosinophils derived from allergic patients and a leukemic cell line via p53 pathway. Recently, SP-D has been shown to suppress lung cancer progression via interference with the epidermal growth factor signaling. In addition, a truncated form of recombinant human SP-D has been reported to induce apoptosis in pancreatic adenocarcinoma via Fas-mediated pathway in a p53-independent manner. To further establish a correlation between SP-D presence/levels and normal and cancer tissues, we performed a bioinformatics analysis, using Oncomine dataset and the survival analysis platforms Kaplan–Meier plotter, to assess if SP-D can serve as a potential prognostic marker for human lung cancer, in addition to human gastric, breast, and ovarian cancers. We also analyzed immunohistochemically the presence of SP-D in normal and tumor human tissues. We conclude that (1) in the lung, gastric, and breast cancers, there is a lower expression of SP-D than normal tissues; (2) in ovarian cancer, there is a higher expression of SP-D than normal tissue; and (3) in lung cancer, the presence of SP-D could be associated with a favorable prognosis. On the contrary, at non-pulmonary sites such as gastric, breast, and ovarian cancers, the presence of SP-D could be associated with unfavorable prognosis. Correlation between the levels of SP-D and overall survival requires further investigation. Our analysis involves a large number of dataset; therefore, any trend observed is reliable. Despite apparent complexity within the results, it is evident that cancer tissues that produce less levels of SP-D compared to their normal tissue counterparts are probably less susceptible to SP-D-mediated immune surveillance mechanisms via infiltrating immune cells. Frontiers Media S.A. 2018-08-06 /pmc/articles/PMC6088209/ /pubmed/30127783 http://dx.doi.org/10.3389/fimmu.2018.01748 Text en Copyright © 2018 Mangogna, Belmonte, Agostinis, Ricci, Gulino, Ferrara, Zanconati, Tripodo, Romano, Kishore and Bulla. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Mangogna, Alessandro Belmonte, Beatrice Agostinis, Chiara Ricci, Giuseppe Gulino, Alessandro Ferrara, Ines Zanconati, Fabrizio Tripodo, Claudio Romano, Federico Kishore, Uday Bulla, Roberta Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer |
title | Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer |
title_full | Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer |
title_fullStr | Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer |
title_full_unstemmed | Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer |
title_short | Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer |
title_sort | pathological significance and prognostic value of surfactant protein d in cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088209/ https://www.ncbi.nlm.nih.gov/pubmed/30127783 http://dx.doi.org/10.3389/fimmu.2018.01748 |
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