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Cryptic binding sites on proteins: definition, detection, and druggability
Many proteins in their unbound structures lack surface pockets appropriately sized for drug binding. Hence, a variety of experimental and computational tools have been developed for the identification of cryptic sites that are not evident in the unbound protein but form upon ligand binding, and can...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088748/ https://www.ncbi.nlm.nih.gov/pubmed/29800865 http://dx.doi.org/10.1016/j.cbpa.2018.05.003 |