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Is paliperidone palmitate more effective than other long-acting injectable antipsychotics?
BACKGROUND: Paliperidone palmitate is one of the most widely prescribed long-acting injectable (LAI) antipsychotics in the UK. However, it is relatively expensive and there are few data comparing its effectiveness to that of other LAI antipsychotics. We sought to address this issue by analyzing a la...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088783/ https://www.ncbi.nlm.nih.gov/pubmed/29039277 http://dx.doi.org/10.1017/S0033291717003051 |
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author | Patel, R. Chesney, E. Taylor, M. Taylor, D. McGuire, P. |
author_facet | Patel, R. Chesney, E. Taylor, M. Taylor, D. McGuire, P. |
author_sort | Patel, R. |
collection | PubMed |
description | BACKGROUND: Paliperidone palmitate is one of the most widely prescribed long-acting injectable (LAI) antipsychotics in the UK. However, it is relatively expensive and there are few data comparing its effectiveness to that of other LAI antipsychotics. We sought to address this issue by analyzing a large anonymized electronic health record (EHR) dataset from patients treated with LAI antipsychotics. METHODS: EHR data were obtained from 1281 patients in the South London and Maudsley NHS Foundation Trust (SLaM) who started treatment with a LAI antipsychotic between 1 April 2011 and 31 January 2015. The number of days spent as a psychiatric inpatient and the number of admissions to a psychiatric hospital were analyzed in each of the 3 years before and after LAI prescription. RESULTS: Patients treated with paliperidone palmitate (n = 430; 33.6%) had a greater number of inpatient days and a greater number of admissions in the year prior to treatment than those treated with other LAI antipsychotics. Nevertheless, in the 3 years after initiation there were no significant differences between paliperidone and the other LAI antipsychotics in the number of days as an inpatient (B coefficient 5.4 days, 95% confidence interval (CI) −57.3 to 68.2, p = 0.86) or number of hospital admissions (Incidence rate ratio 1.07, 95% CI 0.62 to 1.83, p = 0.82). CONCLUSION: Paliperidone palmitate was more likely to be prescribed in patients with more frequent and lengthy hospital admissions prior to initiation. However, the absence of differences in outcomes after initiation indicates that paliperidone palmitate was not more effective than other cheaper LAI antipsychotics. |
format | Online Article Text |
id | pubmed-6088783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60887832018-08-16 Is paliperidone palmitate more effective than other long-acting injectable antipsychotics? Patel, R. Chesney, E. Taylor, M. Taylor, D. McGuire, P. Psychol Med Original Articles BACKGROUND: Paliperidone palmitate is one of the most widely prescribed long-acting injectable (LAI) antipsychotics in the UK. However, it is relatively expensive and there are few data comparing its effectiveness to that of other LAI antipsychotics. We sought to address this issue by analyzing a large anonymized electronic health record (EHR) dataset from patients treated with LAI antipsychotics. METHODS: EHR data were obtained from 1281 patients in the South London and Maudsley NHS Foundation Trust (SLaM) who started treatment with a LAI antipsychotic between 1 April 2011 and 31 January 2015. The number of days spent as a psychiatric inpatient and the number of admissions to a psychiatric hospital were analyzed in each of the 3 years before and after LAI prescription. RESULTS: Patients treated with paliperidone palmitate (n = 430; 33.6%) had a greater number of inpatient days and a greater number of admissions in the year prior to treatment than those treated with other LAI antipsychotics. Nevertheless, in the 3 years after initiation there were no significant differences between paliperidone and the other LAI antipsychotics in the number of days as an inpatient (B coefficient 5.4 days, 95% confidence interval (CI) −57.3 to 68.2, p = 0.86) or number of hospital admissions (Incidence rate ratio 1.07, 95% CI 0.62 to 1.83, p = 0.82). CONCLUSION: Paliperidone palmitate was more likely to be prescribed in patients with more frequent and lengthy hospital admissions prior to initiation. However, the absence of differences in outcomes after initiation indicates that paliperidone palmitate was not more effective than other cheaper LAI antipsychotics. Cambridge University Press 2018-07 2017-10-17 /pmc/articles/PMC6088783/ /pubmed/29039277 http://dx.doi.org/10.1017/S0033291717003051 Text en © Cambridge University Press 2017 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Patel, R. Chesney, E. Taylor, M. Taylor, D. McGuire, P. Is paliperidone palmitate more effective than other long-acting injectable antipsychotics? |
title | Is paliperidone palmitate more effective than other long-acting injectable antipsychotics? |
title_full | Is paliperidone palmitate more effective than other long-acting injectable antipsychotics? |
title_fullStr | Is paliperidone palmitate more effective than other long-acting injectable antipsychotics? |
title_full_unstemmed | Is paliperidone palmitate more effective than other long-acting injectable antipsychotics? |
title_short | Is paliperidone palmitate more effective than other long-acting injectable antipsychotics? |
title_sort | is paliperidone palmitate more effective than other long-acting injectable antipsychotics? |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088783/ https://www.ncbi.nlm.nih.gov/pubmed/29039277 http://dx.doi.org/10.1017/S0033291717003051 |
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