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Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse

PURPOSE: A detailed analysis of hepatitis C virus (HCV) resistance-associated substitutions (RASs) is required to understand why people fail direct-acting antiviral therapies. This study was conducted to assess RASs in an analysis of 2 trials evaluating the second-generation NS3/4A protease inhibito...

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Detalles Bibliográficos
Autores principales:	Bonsall, David, Black, Stuart, Howe, Anita YM, Chase, Robert, Ingravallo, Paul, Pak, Irene, Brown, Anthony, Smith, David A, Bowden, Rory, Barnes, Eleanor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089106/ https://www.ncbi.nlm.nih.gov/pubmed/30127629 http://dx.doi.org/10.2147/IDR.S156581

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