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3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation
PURPOSE: To assess tracheobronchial angles and their changes on combined inspiratory and expiratory thoracic computed tomography (CT) scans and to determine correlations between tracheobronchial angles and several indices of chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: A tota...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089108/ https://www.ncbi.nlm.nih.gov/pubmed/30127602 http://dx.doi.org/10.2147/COPD.S165824 |
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author | Onoe, Rintaro Yamashiro, Tsuneo Handa, Hiroshi Azagami, Shinya Matsuoka, Shin Inoue, Takeo Miyazawa, Teruomi Mineshita, Masamichi |
author_facet | Onoe, Rintaro Yamashiro, Tsuneo Handa, Hiroshi Azagami, Shinya Matsuoka, Shin Inoue, Takeo Miyazawa, Teruomi Mineshita, Masamichi |
author_sort | Onoe, Rintaro |
collection | PubMed |
description | PURPOSE: To assess tracheobronchial angles and their changes on combined inspiratory and expiratory thoracic computed tomography (CT) scans and to determine correlations between tracheobronchial angles and several indices of chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: A total of 80 smokers underwent combined inspiratory and expiratory CT scans. Of these, 65 subjects also performed spirometry and 55 patients were diagnosed with COPD. On CT scans, 3-dimensinal tracheobronchial angles (trachea–right main bronchus [RMB], trachea–left main bronchus [LMB], and RMB–LMB) were automatically measured by software. Lung volumes at inspiration and expiration were also automatically calculated. Changes in tracheobronchial angles between inspiration and expiration were assessed by the Mann–Whitney test. Correlations of the angles with lung volume, airflow limitation, and CT-based emphysema index were evaluated by Spearman rank correlation. RESULTS: The trachea–LMB angle was significantly smaller and the RMB–LMB angle was significantly larger at expiration than inspiration (P<0.0001). The trachea–LMB and RMB–LMB angles were significantly correlated with lung volume, particularly at expiration. The RMB–LMB angle was significantly correlated with airflow limitation and CT emphysema index (P<0.001–0.05) at inspiration and expiration, suggesting that narrowed RMB–LMB angle indicates more severe airflow limitation and larger extent of emphysema. CONCLUSION: Tracheobronchial angles change during respiration and are correlated with severity of COPD and emphysema. |
format | Online Article Text |
id | pubmed-6089108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60891082018-08-20 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation Onoe, Rintaro Yamashiro, Tsuneo Handa, Hiroshi Azagami, Shinya Matsuoka, Shin Inoue, Takeo Miyazawa, Teruomi Mineshita, Masamichi Int J Chron Obstruct Pulmon Dis Original Research PURPOSE: To assess tracheobronchial angles and their changes on combined inspiratory and expiratory thoracic computed tomography (CT) scans and to determine correlations between tracheobronchial angles and several indices of chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: A total of 80 smokers underwent combined inspiratory and expiratory CT scans. Of these, 65 subjects also performed spirometry and 55 patients were diagnosed with COPD. On CT scans, 3-dimensinal tracheobronchial angles (trachea–right main bronchus [RMB], trachea–left main bronchus [LMB], and RMB–LMB) were automatically measured by software. Lung volumes at inspiration and expiration were also automatically calculated. Changes in tracheobronchial angles between inspiration and expiration were assessed by the Mann–Whitney test. Correlations of the angles with lung volume, airflow limitation, and CT-based emphysema index were evaluated by Spearman rank correlation. RESULTS: The trachea–LMB angle was significantly smaller and the RMB–LMB angle was significantly larger at expiration than inspiration (P<0.0001). The trachea–LMB and RMB–LMB angles were significantly correlated with lung volume, particularly at expiration. The RMB–LMB angle was significantly correlated with airflow limitation and CT emphysema index (P<0.001–0.05) at inspiration and expiration, suggesting that narrowed RMB–LMB angle indicates more severe airflow limitation and larger extent of emphysema. CONCLUSION: Tracheobronchial angles change during respiration and are correlated with severity of COPD and emphysema. Dove Medical Press 2018-08-10 /pmc/articles/PMC6089108/ /pubmed/30127602 http://dx.doi.org/10.2147/COPD.S165824 Text en © 2018 Onoe et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Onoe, Rintaro Yamashiro, Tsuneo Handa, Hiroshi Azagami, Shinya Matsuoka, Shin Inoue, Takeo Miyazawa, Teruomi Mineshita, Masamichi 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation |
title | 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation |
title_full | 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation |
title_fullStr | 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation |
title_full_unstemmed | 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation |
title_short | 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation |
title_sort | 3d-measurement of tracheobronchial angles on inspiratory and expiratory chest ct in copd: respiratory changes and correlation with airflow limitation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089108/ https://www.ncbi.nlm.nih.gov/pubmed/30127602 http://dx.doi.org/10.2147/COPD.S165824 |
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