Cargando…
Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study
Few studies have examined the possibility that cachexia may affect men and women differently. This pilot study assessed gender differences in body composition in stomach, colorectal, and biliary cancer patients with cachexia. A sample of 38 participants (Female: Male = 17:21, mean age 57.4 years) we...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089140/ https://www.ncbi.nlm.nih.gov/pubmed/29971962 http://dx.doi.org/10.1002/cam4.1665 |
_version_ | 1783346972053209088 |
---|---|
author | Yoon, Saunjoo L. Grundmann, Oliver Williams, Joseph J. Gordan, Lucio George, Thomas J. |
author_facet | Yoon, Saunjoo L. Grundmann, Oliver Williams, Joseph J. Gordan, Lucio George, Thomas J. |
author_sort | Yoon, Saunjoo L. |
collection | PubMed |
description | Few studies have examined the possibility that cachexia may affect men and women differently. This pilot study assessed gender differences in body composition in stomach, colorectal, and biliary cancer patients with cachexia. A sample of 38 participants (Female: Male = 17:21, mean age 57.4 years) were included if they were undergoing chemotherapy and experienced weight loss of 5% or more over a 6‐month period. Bioelectrical impedance analysis (BIA) was applied to measure body composition. Phase angle (PA) and levels of extra‐/intracellular water (ECW; ICW) were determined. Data were analyzed first by gender and then compared to age‐ and gender‐matched healthy controls from the NHANES‐III dataset. PA was lower (P < .01) in both genders compared with healthy controls, and PA was lower in female patients compared with male patients (P = .03). Male cancer patients with lower PA also had lower ICW levels compared with healthy controls (r = .98, P < .01). For female patients, PA and ICW were negatively correlated (r = .897, P < .01). A lower ECW/ICW ratio was highly correlated (r = .969 for men, r = .639 for women) with increased PA in cancer patients. ICW changes are gender‐specific in patients with GI cancer. ECW/ICW ratios and PA may be suitable surrogate markers for gender‐specific changes in cell composition and health status. |
format | Online Article Text |
id | pubmed-6089140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60891402018-08-17 Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study Yoon, Saunjoo L. Grundmann, Oliver Williams, Joseph J. Gordan, Lucio George, Thomas J. Cancer Med Clinical Cancer Research Few studies have examined the possibility that cachexia may affect men and women differently. This pilot study assessed gender differences in body composition in stomach, colorectal, and biliary cancer patients with cachexia. A sample of 38 participants (Female: Male = 17:21, mean age 57.4 years) were included if they were undergoing chemotherapy and experienced weight loss of 5% or more over a 6‐month period. Bioelectrical impedance analysis (BIA) was applied to measure body composition. Phase angle (PA) and levels of extra‐/intracellular water (ECW; ICW) were determined. Data were analyzed first by gender and then compared to age‐ and gender‐matched healthy controls from the NHANES‐III dataset. PA was lower (P < .01) in both genders compared with healthy controls, and PA was lower in female patients compared with male patients (P = .03). Male cancer patients with lower PA also had lower ICW levels compared with healthy controls (r = .98, P < .01). For female patients, PA and ICW were negatively correlated (r = .897, P < .01). A lower ECW/ICW ratio was highly correlated (r = .969 for men, r = .639 for women) with increased PA in cancer patients. ICW changes are gender‐specific in patients with GI cancer. ECW/ICW ratios and PA may be suitable surrogate markers for gender‐specific changes in cell composition and health status. John Wiley and Sons Inc. 2018-07-03 /pmc/articles/PMC6089140/ /pubmed/29971962 http://dx.doi.org/10.1002/cam4.1665 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Yoon, Saunjoo L. Grundmann, Oliver Williams, Joseph J. Gordan, Lucio George, Thomas J. Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study |
title | Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study |
title_full | Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study |
title_fullStr | Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study |
title_full_unstemmed | Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study |
title_short | Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study |
title_sort | body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: results from a pilot study |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089140/ https://www.ncbi.nlm.nih.gov/pubmed/29971962 http://dx.doi.org/10.1002/cam4.1665 |
work_keys_str_mv | AT yoonsaunjool bodycompositionchangesdifferbygenderinstomachcolorectalandbiliarycancerpatientswithcachexiaresultsfromapilotstudy AT grundmannoliver bodycompositionchangesdifferbygenderinstomachcolorectalandbiliarycancerpatientswithcachexiaresultsfromapilotstudy AT williamsjosephj bodycompositionchangesdifferbygenderinstomachcolorectalandbiliarycancerpatientswithcachexiaresultsfromapilotstudy AT gordanlucio bodycompositionchangesdifferbygenderinstomachcolorectalandbiliarycancerpatientswithcachexiaresultsfromapilotstudy AT georgethomasj bodycompositionchangesdifferbygenderinstomachcolorectalandbiliarycancerpatientswithcachexiaresultsfromapilotstudy |