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HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers

The cancers are the leading cause of disease‐related deaths worldwide with a high risk of morbidity and mortality. Long noncoding RNAs (lncRNAs) play a critical role in a wide range of biological processes, including tumorigenesis. HOXA11‐AS (NCRNA00076), the antisense strands of HOXA11 gene, was in...

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Autores principales: Lu, Cheng‐Wei, Zhou, Dan‐Dan, Xie, Tian, Hao, Ji‐Long, Pant, Om Prakash, Lu, Cheng‐Bo, Liu, Xiu‐Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089141/
https://www.ncbi.nlm.nih.gov/pubmed/29992790
http://dx.doi.org/10.1002/cam4.1571
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author Lu, Cheng‐Wei
Zhou, Dan‐Dan
Xie, Tian
Hao, Ji‐Long
Pant, Om Prakash
Lu, Cheng‐Bo
Liu, Xiu‐Fen
author_facet Lu, Cheng‐Wei
Zhou, Dan‐Dan
Xie, Tian
Hao, Ji‐Long
Pant, Om Prakash
Lu, Cheng‐Bo
Liu, Xiu‐Fen
author_sort Lu, Cheng‐Wei
collection PubMed
description The cancers are the leading cause of disease‐related deaths worldwide with a high risk of morbidity and mortality. Long noncoding RNAs (lncRNAs) play a critical role in a wide range of biological processes, including tumorigenesis. HOXA11‐AS (NCRNA00076), the antisense strands of HOXA11 gene, was initially revealed in a mouse embryonic cDNA library in 2009 and it was a fairly novel lncRNA. This review summarized the advanced research progression concerning the expression and role of HOXA11‐AS in different human malignancies. The expression of HOXA11‐AS is aberrantly altered in many cancers, either as a tumor suppressor or as a tumor accelerator. The different underlying mechanism of HOXA11‐AS in different cancers (including, nonsmall cell lung cancers, osteosarcoma, uveal melanoma, glioma, hepatocellular carcinoma, gastric cancer, breast cancer, cervical cancer, ovarian cancer, colorectal cancer, ovarian cancer, and glioblastoma) was also detailed. These findings lead us to conclude that HOXA11‐AS participate in the complex network of cancers and plays an important role in the tumorigenesis and progression. Functional HOXA11‐AS could be a promising biomarker for early detection as well as prognosis evaluation in cancer patients. Future HOXA11‐AS‐targeted intervention may become a valuable novel therapeutic tool, improving the clinical management of cancers.
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spelling pubmed-60891412018-08-17 HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers Lu, Cheng‐Wei Zhou, Dan‐Dan Xie, Tian Hao, Ji‐Long Pant, Om Prakash Lu, Cheng‐Bo Liu, Xiu‐Fen Cancer Med Cancer Biology The cancers are the leading cause of disease‐related deaths worldwide with a high risk of morbidity and mortality. Long noncoding RNAs (lncRNAs) play a critical role in a wide range of biological processes, including tumorigenesis. HOXA11‐AS (NCRNA00076), the antisense strands of HOXA11 gene, was initially revealed in a mouse embryonic cDNA library in 2009 and it was a fairly novel lncRNA. This review summarized the advanced research progression concerning the expression and role of HOXA11‐AS in different human malignancies. The expression of HOXA11‐AS is aberrantly altered in many cancers, either as a tumor suppressor or as a tumor accelerator. The different underlying mechanism of HOXA11‐AS in different cancers (including, nonsmall cell lung cancers, osteosarcoma, uveal melanoma, glioma, hepatocellular carcinoma, gastric cancer, breast cancer, cervical cancer, ovarian cancer, colorectal cancer, ovarian cancer, and glioblastoma) was also detailed. These findings lead us to conclude that HOXA11‐AS participate in the complex network of cancers and plays an important role in the tumorigenesis and progression. Functional HOXA11‐AS could be a promising biomarker for early detection as well as prognosis evaluation in cancer patients. Future HOXA11‐AS‐targeted intervention may become a valuable novel therapeutic tool, improving the clinical management of cancers. John Wiley and Sons Inc. 2018-07-10 /pmc/articles/PMC6089141/ /pubmed/29992790 http://dx.doi.org/10.1002/cam4.1571 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Lu, Cheng‐Wei
Zhou, Dan‐Dan
Xie, Tian
Hao, Ji‐Long
Pant, Om Prakash
Lu, Cheng‐Bo
Liu, Xiu‐Fen
HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers
title HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers
title_full HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers
title_fullStr HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers
title_full_unstemmed HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers
title_short HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers
title_sort hoxa11 antisense long noncoding rna (hoxa11‐as): a promising lncrna in human cancers
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089141/
https://www.ncbi.nlm.nih.gov/pubmed/29992790
http://dx.doi.org/10.1002/cam4.1571
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