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Risk factors for upper tract urothelial recurrence following local excision of bladder cancer

The mechanism of upper tract recurrence after local excision of bladder cancer remains unknown. This study was designed to identify risk factors for upper tract urothelial recurrence following local tumor excision of bladder cancer. To identify 76 597 bladder cancer patients, comprising 76 537 nonre...

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Autores principales: Lin, Ning, Wu, Yu‐Peng, Lin, Yun‐Zhi, Tao, Xuan, Chen, Shao‐Hao, Ke, Zhi‐Bin, Wei, Yong, Zheng, Qing‐Shui, Xue, Xue‐Yi, Xu, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089153/
https://www.ncbi.nlm.nih.gov/pubmed/29953747
http://dx.doi.org/10.1002/cam4.1642
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author Lin, Ning
Wu, Yu‐Peng
Lin, Yun‐Zhi
Tao, Xuan
Chen, Shao‐Hao
Ke, Zhi‐Bin
Wei, Yong
Zheng, Qing‐Shui
Xue, Xue‐Yi
Xu, Ning
author_facet Lin, Ning
Wu, Yu‐Peng
Lin, Yun‐Zhi
Tao, Xuan
Chen, Shao‐Hao
Ke, Zhi‐Bin
Wei, Yong
Zheng, Qing‐Shui
Xue, Xue‐Yi
Xu, Ning
author_sort Lin, Ning
collection PubMed
description The mechanism of upper tract recurrence after local excision of bladder cancer remains unknown. This study was designed to identify risk factors for upper tract urothelial recurrence following local tumor excision of bladder cancer. To identify 76 597 bladder cancer patients, comprising 76 537 nonrecurrence and 60 recurrence patients, the Surveillance, Epidemiology, and End Results database was used. Kaplan‐Meier analysis and univariate and multivariate Cox proportional hazards regression models were used to determine the risk factors. Compared with the nonrecurrence group, the recurrence group was associated with older age, higher grade, high T stage, and higher proportional squamous cell carcinomas. Univariate Cox proportional hazards regression model showed that age, grades III and IV, T stage, and pathology were significantly associated with worse upper tract urothelial recurrence (UTUR) survival. However, after adjusting for prognostic factors, grade was no longer an independent prognostic factor in multivariate analysis. This study demonstrates that clinical prognosis of UTUR after local bladder tumor excision has significant independent risk factors that include age ≥60 years, T1 and T2 stage, and squamous cell carcinoma, and will require more careful consideration during follow‐up.
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spelling pubmed-60891532018-08-17 Risk factors for upper tract urothelial recurrence following local excision of bladder cancer Lin, Ning Wu, Yu‐Peng Lin, Yun‐Zhi Tao, Xuan Chen, Shao‐Hao Ke, Zhi‐Bin Wei, Yong Zheng, Qing‐Shui Xue, Xue‐Yi Xu, Ning Cancer Med Cancer Prevention The mechanism of upper tract recurrence after local excision of bladder cancer remains unknown. This study was designed to identify risk factors for upper tract urothelial recurrence following local tumor excision of bladder cancer. To identify 76 597 bladder cancer patients, comprising 76 537 nonrecurrence and 60 recurrence patients, the Surveillance, Epidemiology, and End Results database was used. Kaplan‐Meier analysis and univariate and multivariate Cox proportional hazards regression models were used to determine the risk factors. Compared with the nonrecurrence group, the recurrence group was associated with older age, higher grade, high T stage, and higher proportional squamous cell carcinomas. Univariate Cox proportional hazards regression model showed that age, grades III and IV, T stage, and pathology were significantly associated with worse upper tract urothelial recurrence (UTUR) survival. However, after adjusting for prognostic factors, grade was no longer an independent prognostic factor in multivariate analysis. This study demonstrates that clinical prognosis of UTUR after local bladder tumor excision has significant independent risk factors that include age ≥60 years, T1 and T2 stage, and squamous cell carcinoma, and will require more careful consideration during follow‐up. John Wiley and Sons Inc. 2018-06-28 /pmc/articles/PMC6089153/ /pubmed/29953747 http://dx.doi.org/10.1002/cam4.1642 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Lin, Ning
Wu, Yu‐Peng
Lin, Yun‐Zhi
Tao, Xuan
Chen, Shao‐Hao
Ke, Zhi‐Bin
Wei, Yong
Zheng, Qing‐Shui
Xue, Xue‐Yi
Xu, Ning
Risk factors for upper tract urothelial recurrence following local excision of bladder cancer
title Risk factors for upper tract urothelial recurrence following local excision of bladder cancer
title_full Risk factors for upper tract urothelial recurrence following local excision of bladder cancer
title_fullStr Risk factors for upper tract urothelial recurrence following local excision of bladder cancer
title_full_unstemmed Risk factors for upper tract urothelial recurrence following local excision of bladder cancer
title_short Risk factors for upper tract urothelial recurrence following local excision of bladder cancer
title_sort risk factors for upper tract urothelial recurrence following local excision of bladder cancer
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089153/
https://www.ncbi.nlm.nih.gov/pubmed/29953747
http://dx.doi.org/10.1002/cam4.1642
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