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Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis

INTRODUCTION: Population‐based data on the incidence and prognosis of bone metastases at diagnosis of breast cancer are currently limited. Hence, we conducted this study to analyze the incidence proportions and prognostic factors of patients with breast cancer and bone metastases at the time of canc...

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Autores principales: Gong, Yue, Zhang, Jing, Ji, Peng, Ling, Hong, Hu, Xin, Shao, Zhi‐Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089179/
https://www.ncbi.nlm.nih.gov/pubmed/29984914
http://dx.doi.org/10.1002/cam4.1668
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author Gong, Yue
Zhang, Jing
Ji, Peng
Ling, Hong
Hu, Xin
Shao, Zhi‐Ming
author_facet Gong, Yue
Zhang, Jing
Ji, Peng
Ling, Hong
Hu, Xin
Shao, Zhi‐Ming
author_sort Gong, Yue
collection PubMed
description INTRODUCTION: Population‐based data on the incidence and prognosis of bone metastases at diagnosis of breast cancer are currently limited. Hence, we conducted this study to analyze the incidence proportions and prognostic factors of patients with breast cancer and bone metastases at the time of cancer diagnosis. MATERIALS AND METHODS: Patients with primary invasive breast cancer and bone metastases at initial diagnosis between 2010 and 2014 were identified using the Surveillance, Epidemiology, and End Results (SEER) dataset and Fudan University Shanghai Cancer Center (FUSCC) cohort. Multivariable logistic regression was performed to identify predictors of the presence of bone metastases at diagnosis. Univariate and multivariate analyses were performed to determine the effects of each variable on survival. RESULTS: Of 229, 195 patients from SEER database included in the analysis, 8295 patients had bone metastases at initial diagnosis, reflecting 3.6% of the entire study population, and 65.1% of the subset with metastatic disease to any distant site. Patients with hormone receptor (HR)‐positive human epidermal growth factor receptor 2 (HER2)‐negative represented the highest incidence proportions among patients with metastatic disease (73.9%). Among entire cohort, multivariable logistic regression identified eight factors as predictors of the presence of bone metastases at diagnosis. Median OS for the patients with bone metastases in SEER and FUSCC cohorts was 30.0 and 68.2 months, respectively. Patients with HR‐positive HER2‐positive subtype had the longest median OS, and patients with triple‐negative subtype showed the shortest median OS. Multivariable Cox model in SEER cohort confirmed age, histology, grade, tumor subtype, extraosseous metastatic sites, history of primary surgery, insurance status, marital status, and income as independent prognostic factors for both OS and BCSS. CONCLUSIONS: The findings of this study provide population‐based estimates of the incidence and prognosis for patients with bone metastases at initial diagnosis of breast cancer.
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spelling pubmed-60891792018-08-17 Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis Gong, Yue Zhang, Jing Ji, Peng Ling, Hong Hu, Xin Shao, Zhi‐Ming Cancer Med Cancer Prevention INTRODUCTION: Population‐based data on the incidence and prognosis of bone metastases at diagnosis of breast cancer are currently limited. Hence, we conducted this study to analyze the incidence proportions and prognostic factors of patients with breast cancer and bone metastases at the time of cancer diagnosis. MATERIALS AND METHODS: Patients with primary invasive breast cancer and bone metastases at initial diagnosis between 2010 and 2014 were identified using the Surveillance, Epidemiology, and End Results (SEER) dataset and Fudan University Shanghai Cancer Center (FUSCC) cohort. Multivariable logistic regression was performed to identify predictors of the presence of bone metastases at diagnosis. Univariate and multivariate analyses were performed to determine the effects of each variable on survival. RESULTS: Of 229, 195 patients from SEER database included in the analysis, 8295 patients had bone metastases at initial diagnosis, reflecting 3.6% of the entire study population, and 65.1% of the subset with metastatic disease to any distant site. Patients with hormone receptor (HR)‐positive human epidermal growth factor receptor 2 (HER2)‐negative represented the highest incidence proportions among patients with metastatic disease (73.9%). Among entire cohort, multivariable logistic regression identified eight factors as predictors of the presence of bone metastases at diagnosis. Median OS for the patients with bone metastases in SEER and FUSCC cohorts was 30.0 and 68.2 months, respectively. Patients with HR‐positive HER2‐positive subtype had the longest median OS, and patients with triple‐negative subtype showed the shortest median OS. Multivariable Cox model in SEER cohort confirmed age, histology, grade, tumor subtype, extraosseous metastatic sites, history of primary surgery, insurance status, marital status, and income as independent prognostic factors for both OS and BCSS. CONCLUSIONS: The findings of this study provide population‐based estimates of the incidence and prognosis for patients with bone metastases at initial diagnosis of breast cancer. John Wiley and Sons Inc. 2018-07-09 /pmc/articles/PMC6089179/ /pubmed/29984914 http://dx.doi.org/10.1002/cam4.1668 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Gong, Yue
Zhang, Jing
Ji, Peng
Ling, Hong
Hu, Xin
Shao, Zhi‐Ming
Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
title Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
title_full Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
title_fullStr Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
title_full_unstemmed Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
title_short Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
title_sort incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089179/
https://www.ncbi.nlm.nih.gov/pubmed/29984914
http://dx.doi.org/10.1002/cam4.1668
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