Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H(+)‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in...

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Detalles Bibliográficos
Autores principales: Whitton, Bradleigh, Okamoto, Haruko, Packham, Graham, Crabb, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089187/
https://www.ncbi.nlm.nih.gov/pubmed/29926527
http://dx.doi.org/10.1002/cam4.1594
Descripción
Sumario:Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H(+)‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in cancer. This includes how V‐ATPase dysregulation contributes to cancer growth, metastasis, invasion and proliferation, and the potential link between V‐ATPase and the development of drug resistance.

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