Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H(+)‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in...

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Detalles Bibliográficos
Autores principales: Whitton, Bradleigh, Okamoto, Haruko, Packham, Graham, Crabb, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089187/
https://www.ncbi.nlm.nih.gov/pubmed/29926527
http://dx.doi.org/10.1002/cam4.1594
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author Whitton, Bradleigh
Okamoto, Haruko
Packham, Graham
Crabb, Simon J.
author_facet Whitton, Bradleigh
Okamoto, Haruko
Packham, Graham
Crabb, Simon J.
author_sort Whitton, Bradleigh
collection PubMed
description Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H(+)‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in cancer. This includes how V‐ATPase dysregulation contributes to cancer growth, metastasis, invasion and proliferation, and the potential link between V‐ATPase and the development of drug resistance.
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spelling pubmed-60891872018-08-17 Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer Whitton, Bradleigh Okamoto, Haruko Packham, Graham Crabb, Simon J. Cancer Med Cancer Biology Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H(+)‐transporter that pumps protons across intracellular and plasma membranes. It consists of a large multi‐subunit protein complex and influences a wide range of cellular processes. This review focuses on emerging evidence for the roles for V‐ATPase in cancer. This includes how V‐ATPase dysregulation contributes to cancer growth, metastasis, invasion and proliferation, and the potential link between V‐ATPase and the development of drug resistance. John Wiley and Sons Inc. 2018-06-21 /pmc/articles/PMC6089187/ /pubmed/29926527 http://dx.doi.org/10.1002/cam4.1594 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Whitton, Bradleigh
Okamoto, Haruko
Packham, Graham
Crabb, Simon J.
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
title Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
title_full Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
title_fullStr Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
title_full_unstemmed Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
title_short Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer
title_sort vacuolar atpase as a potential therapeutic target and mediator of treatment resistance in cancer
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089187/
https://www.ncbi.nlm.nih.gov/pubmed/29926527
http://dx.doi.org/10.1002/cam4.1594
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AT packhamgraham vacuolaratpaseasapotentialtherapeutictargetandmediatoroftreatmentresistanceincancer
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