Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

Medulloblastoma (MB) is the most common type of malignant childhood brain tumor. We previously showed that inhibitors of apoptosis proteins (IAP) small‐molecule inhibitors (LCL161 or LBW242) combined with chemotherapy have synergistic antiproliferative effects on MB cells. The synergistic antitumor...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Shu‐Mei, Lin, Tzu‐Kang, Tseng, Yuan‐Yun, Tu, Chiao‐Hui, Lui, Tai‐Ngar, Huang, Shiang‐Fu, Hsieh, Ling‐Ling, Li, Ying‐Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089189/
https://www.ncbi.nlm.nih.gov/pubmed/29984917
http://dx.doi.org/10.1002/cam4.1658

Ejemplares similares

Ejemplares similares