Etidronate prevents, but does not reverse, ectopic mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(−/−))

Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are heritable disorders manifesting with ectopic tissue mineralization. Most cases of PXE and some cases of GACI are caused by mutations in the ABCC6 gene, resulting in reduced plasma pyrophosphate (PPi) levels....

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Detalles Bibliográficos
Autores principales: Li, Qiaoli, Kingman, Joshua, Sundberg, John P., Levine, Michael A., Uitto, Jouni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089405/
https://www.ncbi.nlm.nih.gov/pubmed/30112102
http://dx.doi.org/10.18632/oncotarget.10738

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