Cargando…

Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy

Background: Intrathecal baclofen (ITB) administration via an implanted programmable pump and selective dorsal rhizotomy (SDR) are both used for the treatment of cerebral palsy (CP) spasticity. Objective: To examine whether SDR can improve ambulation in children who have been receiving ITB therapy fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, TS, Miller, Brandon A, Cho, Junsang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089480/
https://www.ncbi.nlm.nih.gov/pubmed/30112267
http://dx.doi.org/10.7759/cureus.2791
_version_ 1783347030694821888
author Park, TS
Miller, Brandon A
Cho, Junsang
author_facet Park, TS
Miller, Brandon A
Cho, Junsang
author_sort Park, TS
collection PubMed
description Background: Intrathecal baclofen (ITB) administration via an implanted programmable pump and selective dorsal rhizotomy (SDR) are both used for the treatment of cerebral palsy (CP) spasticity. Objective: To examine whether SDR can improve ambulation in children who have been receiving ITB therapy for spastic cerebral palsy. Methods: We reviewed 13 patients who received prior ITB placement with subsequent simultaneous SDR and ITB removal. Patients also completed a follow-up survey to document long-term motor function. Results: In our 13-patient cohort, patients received ITB treatment for an average of 4.4 [Formula: see text] 1.8 years and the mean age of ITB removal/SDR was 12.5  [Formula: see text]  5.8 years. The follow-up period ranged from 3 to 19 months (mean duration: 6.9 [Formula: see text]  5 months). Pre-operatively, all patients had Gross Motor Function Classification System (GMFCS) scores between 2 and 4. Nine patients were diagnosed with spastic diplegia, two had spastic triplegia and two had spastic quadriplegia. SDR and ITB removal led to improved lower limb spasticity and ambulation. GMFCS scores remained stable in all patients. One patient developed a cerebrospinal fluid (CSF) collection in the abdominal wall due to a CSF leak from the baclofen pump site. All 11 patients who completed the follow-up survey noted improved motor function. Conclusion: This study demonstrates that SDR can reduce spasticity and improve mobility after years of ITB treatment for spastic cerebral palsy.
format Online
Article
Text
id pubmed-6089480
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-60894802018-08-15 Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy Park, TS Miller, Brandon A Cho, Junsang Cureus Pediatrics Background: Intrathecal baclofen (ITB) administration via an implanted programmable pump and selective dorsal rhizotomy (SDR) are both used for the treatment of cerebral palsy (CP) spasticity. Objective: To examine whether SDR can improve ambulation in children who have been receiving ITB therapy for spastic cerebral palsy. Methods: We reviewed 13 patients who received prior ITB placement with subsequent simultaneous SDR and ITB removal. Patients also completed a follow-up survey to document long-term motor function. Results: In our 13-patient cohort, patients received ITB treatment for an average of 4.4 [Formula: see text] 1.8 years and the mean age of ITB removal/SDR was 12.5  [Formula: see text]  5.8 years. The follow-up period ranged from 3 to 19 months (mean duration: 6.9 [Formula: see text]  5 months). Pre-operatively, all patients had Gross Motor Function Classification System (GMFCS) scores between 2 and 4. Nine patients were diagnosed with spastic diplegia, two had spastic triplegia and two had spastic quadriplegia. SDR and ITB removal led to improved lower limb spasticity and ambulation. GMFCS scores remained stable in all patients. One patient developed a cerebrospinal fluid (CSF) collection in the abdominal wall due to a CSF leak from the baclofen pump site. All 11 patients who completed the follow-up survey noted improved motor function. Conclusion: This study demonstrates that SDR can reduce spasticity and improve mobility after years of ITB treatment for spastic cerebral palsy. Cureus 2018-06-12 /pmc/articles/PMC6089480/ /pubmed/30112267 http://dx.doi.org/10.7759/cureus.2791 Text en Copyright © 2018, Park et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Park, TS
Miller, Brandon A
Cho, Junsang
Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy
title Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy
title_full Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy
title_fullStr Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy
title_full_unstemmed Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy
title_short Simultaneous Selective Dorsal Rhizotomy and Baclofen Pump Removal Improve Ambulation in Patients with Spastic Cerebral Palsy
title_sort simultaneous selective dorsal rhizotomy and baclofen pump removal improve ambulation in patients with spastic cerebral palsy
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089480/
https://www.ncbi.nlm.nih.gov/pubmed/30112267
http://dx.doi.org/10.7759/cureus.2791
work_keys_str_mv AT parkts simultaneousselectivedorsalrhizotomyandbaclofenpumpremovalimproveambulationinpatientswithspasticcerebralpalsy
AT millerbrandona simultaneousselectivedorsalrhizotomyandbaclofenpumpremovalimproveambulationinpatientswithspasticcerebralpalsy
AT chojunsang simultaneousselectivedorsalrhizotomyandbaclofenpumpremovalimproveambulationinpatientswithspasticcerebralpalsy