Cargando…

The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies

Chronic obstructive pulmonary disease (COPD) is a disorder affecting more than 200 million people around the world, resulting in three million deaths per year. COPD is characterized by the loss of lung tissue and airway remodelling, with chronic inflammation of the airways and progressive destructio...

Descripción completa

Detalles Bibliográficos
Autores principales: Toraldo, Domenico Maurizio, Toraldo, Sara, Conte, Luana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089575/
https://www.ncbi.nlm.nih.gov/pubmed/30116436
http://dx.doi.org/10.14740/jocmr3484w
_version_ 1783347046436044800
author Toraldo, Domenico Maurizio
Toraldo, Sara
Conte, Luana
author_facet Toraldo, Domenico Maurizio
Toraldo, Sara
Conte, Luana
author_sort Toraldo, Domenico Maurizio
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a disorder affecting more than 200 million people around the world, resulting in three million deaths per year. COPD is characterized by the loss of lung tissue and airway remodelling, with chronic inflammation of the airways and progressive destruction of lung parenchyma. The use of stem cells may lead to regenerative processes that address biological damage. However, this approach raises ethical issues that need to be considered in clinical trials using stem cell therapy, such as informed consent, patient recruitment and harm minimization, as well as the inherent uncertainty of these medical procedures on human beings. Indeed, up to now, these experiments have been performed in preclinical studies using animal models, with few studies involving humans. Additional efforts should be made to assess this promising procedure.
format Online
Article
Text
id pubmed-6089575
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elmer Press
record_format MEDLINE/PubMed
spelling pubmed-60895752018-08-16 The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies Toraldo, Domenico Maurizio Toraldo, Sara Conte, Luana J Clin Med Res Review Chronic obstructive pulmonary disease (COPD) is a disorder affecting more than 200 million people around the world, resulting in three million deaths per year. COPD is characterized by the loss of lung tissue and airway remodelling, with chronic inflammation of the airways and progressive destruction of lung parenchyma. The use of stem cells may lead to regenerative processes that address biological damage. However, this approach raises ethical issues that need to be considered in clinical trials using stem cell therapy, such as informed consent, patient recruitment and harm minimization, as well as the inherent uncertainty of these medical procedures on human beings. Indeed, up to now, these experiments have been performed in preclinical studies using animal models, with few studies involving humans. Additional efforts should be made to assess this promising procedure. Elmer Press 2018-09 2018-07-31 /pmc/articles/PMC6089575/ /pubmed/30116436 http://dx.doi.org/10.14740/jocmr3484w Text en Copyright 2018, Toraldo et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Toraldo, Domenico Maurizio
Toraldo, Sara
Conte, Luana
The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies
title The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies
title_full The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies
title_fullStr The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies
title_full_unstemmed The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies
title_short The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies
title_sort clinical use of stem cell research in chronic obstructive pulmonary disease: a critical analysis of current policies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089575/
https://www.ncbi.nlm.nih.gov/pubmed/30116436
http://dx.doi.org/10.14740/jocmr3484w
work_keys_str_mv AT toraldodomenicomaurizio theclinicaluseofstemcellresearchinchronicobstructivepulmonarydiseaseacriticalanalysisofcurrentpolicies
AT toraldosara theclinicaluseofstemcellresearchinchronicobstructivepulmonarydiseaseacriticalanalysisofcurrentpolicies
AT conteluana theclinicaluseofstemcellresearchinchronicobstructivepulmonarydiseaseacriticalanalysisofcurrentpolicies
AT toraldodomenicomaurizio clinicaluseofstemcellresearchinchronicobstructivepulmonarydiseaseacriticalanalysisofcurrentpolicies
AT toraldosara clinicaluseofstemcellresearchinchronicobstructivepulmonarydiseaseacriticalanalysisofcurrentpolicies
AT conteluana clinicaluseofstemcellresearchinchronicobstructivepulmonarydiseaseacriticalanalysisofcurrentpolicies