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Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy

Introduction Requests for muscle biopsy for evaluation of myopathy originate from a variety of different specialties. It is unknown whether the specialty of the referring service affects the likelihood of diagnostic biopsy or the therapeutic usefulness of a biopsy. Methods We reviewed 106 consecutiv...

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Autores principales: Tenny, Steven O, Schmidt, Kyle P, Follett, Kenneth A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089701/
https://www.ncbi.nlm.nih.gov/pubmed/30116679
http://dx.doi.org/10.7759/cureus.2800
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author Tenny, Steven O
Schmidt, Kyle P
Follett, Kenneth A
author_facet Tenny, Steven O
Schmidt, Kyle P
Follett, Kenneth A
author_sort Tenny, Steven O
collection PubMed
description Introduction Requests for muscle biopsy for evaluation of myopathy originate from a variety of different specialties. It is unknown whether the specialty of the referring service affects the likelihood of diagnostic biopsy or the therapeutic usefulness of a biopsy. Methods We reviewed 106 consecutive muscle biopsies requested by healthcare providers in neurology, rheumatology, family medicine, oncology, and gastroenterology. We tested for an association between referring service and whether the biopsy yielded a definitive pathology result or provided therapeutically useful results. Results Half of the biopsies (49%) returned definitive pathology and 88% of the biopsies provided information that contributed to therapeutic decisions. The diagnostic yield for muscle biopsies referred by different services was not statistically significant (p-value 0.1344) nor was the therapeutic yield statistically significant for muscle biopsies referred by different services (p-value 0.5525). Discussion The specialty of the service that requests a muscle biopsy does not influence the likelihood of obtaining a definitive pathological diagnosis or therapeutically useful information. Other factors may be more important in determining the likelihood of obtaining a clinically useful biopsy result.
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spelling pubmed-60897012018-08-16 Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy Tenny, Steven O Schmidt, Kyle P Follett, Kenneth A Cureus Neurology Introduction Requests for muscle biopsy for evaluation of myopathy originate from a variety of different specialties. It is unknown whether the specialty of the referring service affects the likelihood of diagnostic biopsy or the therapeutic usefulness of a biopsy. Methods We reviewed 106 consecutive muscle biopsies requested by healthcare providers in neurology, rheumatology, family medicine, oncology, and gastroenterology. We tested for an association between referring service and whether the biopsy yielded a definitive pathology result or provided therapeutically useful results. Results Half of the biopsies (49%) returned definitive pathology and 88% of the biopsies provided information that contributed to therapeutic decisions. The diagnostic yield for muscle biopsies referred by different services was not statistically significant (p-value 0.1344) nor was the therapeutic yield statistically significant for muscle biopsies referred by different services (p-value 0.5525). Discussion The specialty of the service that requests a muscle biopsy does not influence the likelihood of obtaining a definitive pathological diagnosis or therapeutically useful information. Other factors may be more important in determining the likelihood of obtaining a clinically useful biopsy result. Cureus 2018-06-13 /pmc/articles/PMC6089701/ /pubmed/30116679 http://dx.doi.org/10.7759/cureus.2800 Text en Copyright © 2018, Tenny et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Tenny, Steven O
Schmidt, Kyle P
Follett, Kenneth A
Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy
title Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy
title_full Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy
title_fullStr Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy
title_full_unstemmed Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy
title_short Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy
title_sort referring service effect on muscle biopsy diagnosis and management in myopathy
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089701/
https://www.ncbi.nlm.nih.gov/pubmed/30116679
http://dx.doi.org/10.7759/cureus.2800
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