Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment

There are many novel chemotherapeutic options and targeted therapies available for the treatment of colorectal and pancreatic cancer. Patients with these cancers often have hepatic impairment either from the metastasis to the liver or from the chemotherapy or targeted therapies used to treat the dis...

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Autores principales: Khalid, Sidra, Khalid, Aariez, Clark, Bernadette A, Haddad, Abdo, Spiro, Timothy PP, Daw, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089706/
https://www.ncbi.nlm.nih.gov/pubmed/30116677
http://dx.doi.org/10.7759/cureus.2798
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author Khalid, Sidra
Khalid, Aariez
Clark, Bernadette A
Haddad, Abdo
Spiro, Timothy PP
Daw, Hamed
author_facet Khalid, Sidra
Khalid, Aariez
Clark, Bernadette A
Haddad, Abdo
Spiro, Timothy PP
Daw, Hamed
author_sort Khalid, Sidra
collection PubMed
description There are many novel chemotherapeutic options and targeted therapies available for the treatment of colorectal and pancreatic cancer. Patients with these cancers often have hepatic impairment either from the metastasis to the liver or from the chemotherapy or targeted therapies used to treat the disease. It is important to describe the effects of these agents in patients with hepatic impairment. This article will review the dosage recommendations for the chemotherapy regimens and targeted therapies in colorectal and pancreatic cancer patients in the setting of hepatic impairment.
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spelling pubmed-60897062018-08-16 Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment Khalid, Sidra Khalid, Aariez Clark, Bernadette A Haddad, Abdo Spiro, Timothy PP Daw, Hamed Cureus Internal Medicine There are many novel chemotherapeutic options and targeted therapies available for the treatment of colorectal and pancreatic cancer. Patients with these cancers often have hepatic impairment either from the metastasis to the liver or from the chemotherapy or targeted therapies used to treat the disease. It is important to describe the effects of these agents in patients with hepatic impairment. This article will review the dosage recommendations for the chemotherapy regimens and targeted therapies in colorectal and pancreatic cancer patients in the setting of hepatic impairment. Cureus 2018-06-13 /pmc/articles/PMC6089706/ /pubmed/30116677 http://dx.doi.org/10.7759/cureus.2798 Text en Copyright © 2018, Khalid et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Khalid, Sidra
Khalid, Aariez
Clark, Bernadette A
Haddad, Abdo
Spiro, Timothy PP
Daw, Hamed
Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment
title Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment
title_full Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment
title_fullStr Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment
title_full_unstemmed Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment
title_short Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment
title_sort dosage adjustments for chemotherapy and targeted therapies in colorectal and pancreatic cancer patients with hepatic impairment
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089706/
https://www.ncbi.nlm.nih.gov/pubmed/30116677
http://dx.doi.org/10.7759/cureus.2798
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