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Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPARγ agonists such as rosiglitazone exhibited remarkable preclinical and clinical treatment effects for these two diseases. In this study, a ser...

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Detalles Bibliográficos
Autores principales:	Wu, Xu-Nian, Huang, Ya-Dan, Li, Jin-Xuan, Yu, Yan-Fa, Qian, Zhou, Zhang, Chen, Wu, Yinuo, Luo, Hai-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089849/ https://www.ncbi.nlm.nih.gov/pubmed/30109185 http://dx.doi.org/10.1016/j.apsb.2017.12.007

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