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DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function

The FOXO transcription factor family is a conserved regulator of longevity and the downstream target of insulin/insulin-like signaling. In Caenorhabditis elegans, the FOXO ortholog DAF-16A and D/F isoforms extend lifespan in daf-2 insulin-like receptor mutants. Here we identify the DAF-21/Hsp90 chap...

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Detalles Bibliográficos
Autores principales:	Somogyvári, Milán, Gecse, Eszter, Sőti, Csaba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089956/ https://www.ncbi.nlm.nih.gov/pubmed/30104664 http://dx.doi.org/10.1038/s41598-018-30592-6

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