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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts...

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Autores principales: Ji, Xuemei, Bossé, Yohan, Landi, Maria Teresa, Gui, Jiang, Xiao, Xiangjun, Qian, David, Joubert, Philippe, Lamontagne, Maxime, Li, Yafang, Gorlov, Ivan, de Biasi, Mariella, Han, Younghun, Gorlova, Olga, Hung, Rayjean J., Wu, Xifeng, McKay, James, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil, Johansson, Mattias, Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Chen, Chu, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier A., Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher, Wilkens, Lynne, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Erik H. F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brüske, Irene, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances, Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard, McLaughlin, John, Stevens, Victoria, Nickle, David C., Obeidat, Ma’en, Timens, Wim, Zhu, Bin, Song, Lei, Artigas, María Soler, Tobin, Martin D., Wain, Louise V., Gu, Fangyi, Byun, Jinyoung, Kamal, Ahsan, Zhu, Dakai, Tyndale, Rachel F., Wei, Wei-Qi, Chanock, Stephen, Brennan, Paul, Amos, Christopher I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967/
https://www.ncbi.nlm.nih.gov/pubmed/30104567
http://dx.doi.org/10.1038/s41467-018-05074-y
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author Ji, Xuemei
Bossé, Yohan
Landi, Maria Teresa
Gui, Jiang
Xiao, Xiangjun
Qian, David
Joubert, Philippe
Lamontagne, Maxime
Li, Yafang
Gorlov, Ivan
de Biasi, Mariella
Han, Younghun
Gorlova, Olga
Hung, Rayjean J.
Wu, Xifeng
McKay, James
Zong, Xuchen
Carreras-Torres, Robert
Christiani, David C.
Caporaso, Neil
Johansson, Mattias
Liu, Geoffrey
Bojesen, Stig E.
Le Marchand, Loic
Albanes, Demetrios
Bickeböller, Heike
Aldrich, Melinda C.
Bush, William S.
Tardon, Adonina
Rennert, Gad
Chen, Chu
Teare, M. Dawn
Field, John K.
Kiemeney, Lambertus A.
Lazarus, Philip
Haugen, Aage
Lam, Stephen
Schabath, Matthew B.
Andrew, Angeline S.
Shen, Hongbing
Hong, Yun-Chul
Yuan, Jian-Min
Bertazzi, Pier A.
Pesatori, Angela C.
Ye, Yuanqing
Diao, Nancy
Su, Li
Zhang, Ruyang
Brhane, Yonathan
Leighl, Natasha
Johansen, Jakob S.
Mellemgaard, Anders
Saliba, Walid
Haiman, Christopher
Wilkens, Lynne
Fernandez-Somoano, Ana
Fernandez-Tardon, Guillermo
van der Heijden, Erik H. F. M.
Kim, Jin Hee
Dai, Juncheng
Hu, Zhibin
Davies, Michael P. A.
Marcus, Michael W.
Brunnström, Hans
Manjer, Jonas
Melander, Olle
Muller, David C.
Overvad, Kim
Trichopoulou, Antonia
Tumino, Rosario
Doherty, Jennifer
Goodman, Gary E.
Cox, Angela
Taylor, Fiona
Woll, Penella
Brüske, Irene
Manz, Judith
Muley, Thomas
Risch, Angela
Rosenberger, Albert
Grankvist, Kjell
Johansson, Mikael
Shepherd, Frances
Tsao, Ming-Sound
Arnold, Susanne M.
Haura, Eric B.
Bolca, Ciprian
Holcatova, Ivana
Janout, Vladimir
Kontic, Milica
Lissowska, Jolanta
Mukeria, Anush
Ognjanovic, Simona
Orlowski, Tadeusz M.
Scelo, Ghislaine
Swiatkowska, Beata
Zaridze, David
Bakke, Per
Skaug, Vidar
Zienolddiny, Shanbeh
Duell, Eric J.
Butler, Lesley M.
Koh, Woon-Puay
Gao, Yu-Tang
Houlston, Richard
McLaughlin, John
Stevens, Victoria
Nickle, David C.
Obeidat, Ma’en
Timens, Wim
Zhu, Bin
Song, Lei
Artigas, María Soler
Tobin, Martin D.
Wain, Louise V.
Gu, Fangyi
Byun, Jinyoung
Kamal, Ahsan
Zhu, Dakai
Tyndale, Rachel F.
Wei, Wei-Qi
Chanock, Stephen
Brennan, Paul
Amos, Christopher I.
author_facet Ji, Xuemei
Bossé, Yohan
Landi, Maria Teresa
Gui, Jiang
Xiao, Xiangjun
Qian, David
Joubert, Philippe
Lamontagne, Maxime
Li, Yafang
Gorlov, Ivan
de Biasi, Mariella
Han, Younghun
Gorlova, Olga
Hung, Rayjean J.
Wu, Xifeng
McKay, James
Zong, Xuchen
Carreras-Torres, Robert
Christiani, David C.
Caporaso, Neil
Johansson, Mattias
Liu, Geoffrey
Bojesen, Stig E.
Le Marchand, Loic
Albanes, Demetrios
Bickeböller, Heike
Aldrich, Melinda C.
Bush, William S.
Tardon, Adonina
Rennert, Gad
Chen, Chu
Teare, M. Dawn
Field, John K.
Kiemeney, Lambertus A.
Lazarus, Philip
Haugen, Aage
Lam, Stephen
Schabath, Matthew B.
Andrew, Angeline S.
Shen, Hongbing
Hong, Yun-Chul
Yuan, Jian-Min
Bertazzi, Pier A.
Pesatori, Angela C.
Ye, Yuanqing
Diao, Nancy
Su, Li
Zhang, Ruyang
Brhane, Yonathan
Leighl, Natasha
Johansen, Jakob S.
Mellemgaard, Anders
Saliba, Walid
Haiman, Christopher
Wilkens, Lynne
Fernandez-Somoano, Ana
Fernandez-Tardon, Guillermo
van der Heijden, Erik H. F. M.
Kim, Jin Hee
Dai, Juncheng
Hu, Zhibin
Davies, Michael P. A.
Marcus, Michael W.
Brunnström, Hans
Manjer, Jonas
Melander, Olle
Muller, David C.
Overvad, Kim
Trichopoulou, Antonia
Tumino, Rosario
Doherty, Jennifer
Goodman, Gary E.
Cox, Angela
Taylor, Fiona
Woll, Penella
Brüske, Irene
Manz, Judith
Muley, Thomas
Risch, Angela
Rosenberger, Albert
Grankvist, Kjell
Johansson, Mikael
Shepherd, Frances
Tsao, Ming-Sound
Arnold, Susanne M.
Haura, Eric B.
Bolca, Ciprian
Holcatova, Ivana
Janout, Vladimir
Kontic, Milica
Lissowska, Jolanta
Mukeria, Anush
Ognjanovic, Simona
Orlowski, Tadeusz M.
Scelo, Ghislaine
Swiatkowska, Beata
Zaridze, David
Bakke, Per
Skaug, Vidar
Zienolddiny, Shanbeh
Duell, Eric J.
Butler, Lesley M.
Koh, Woon-Puay
Gao, Yu-Tang
Houlston, Richard
McLaughlin, John
Stevens, Victoria
Nickle, David C.
Obeidat, Ma’en
Timens, Wim
Zhu, Bin
Song, Lei
Artigas, María Soler
Tobin, Martin D.
Wain, Louise V.
Gu, Fangyi
Byun, Jinyoung
Kamal, Ahsan
Zhu, Dakai
Tyndale, Rachel F.
Wei, Wei-Qi
Chanock, Stephen
Brennan, Paul
Amos, Christopher I.
author_sort Ji, Xuemei
collection PubMed
description Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
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spelling pubmed-60899672018-08-15 Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk Ji, Xuemei Bossé, Yohan Landi, Maria Teresa Gui, Jiang Xiao, Xiangjun Qian, David Joubert, Philippe Lamontagne, Maxime Li, Yafang Gorlov, Ivan de Biasi, Mariella Han, Younghun Gorlova, Olga Hung, Rayjean J. Wu, Xifeng McKay, James Zong, Xuchen Carreras-Torres, Robert Christiani, David C. Caporaso, Neil Johansson, Mattias Liu, Geoffrey Bojesen, Stig E. Le Marchand, Loic Albanes, Demetrios Bickeböller, Heike Aldrich, Melinda C. Bush, William S. Tardon, Adonina Rennert, Gad Chen, Chu Teare, M. Dawn Field, John K. Kiemeney, Lambertus A. Lazarus, Philip Haugen, Aage Lam, Stephen Schabath, Matthew B. Andrew, Angeline S. Shen, Hongbing Hong, Yun-Chul Yuan, Jian-Min Bertazzi, Pier A. Pesatori, Angela C. Ye, Yuanqing Diao, Nancy Su, Li Zhang, Ruyang Brhane, Yonathan Leighl, Natasha Johansen, Jakob S. Mellemgaard, Anders Saliba, Walid Haiman, Christopher Wilkens, Lynne Fernandez-Somoano, Ana Fernandez-Tardon, Guillermo van der Heijden, Erik H. F. M. Kim, Jin Hee Dai, Juncheng Hu, Zhibin Davies, Michael P. A. Marcus, Michael W. Brunnström, Hans Manjer, Jonas Melander, Olle Muller, David C. Overvad, Kim Trichopoulou, Antonia Tumino, Rosario Doherty, Jennifer Goodman, Gary E. Cox, Angela Taylor, Fiona Woll, Penella Brüske, Irene Manz, Judith Muley, Thomas Risch, Angela Rosenberger, Albert Grankvist, Kjell Johansson, Mikael Shepherd, Frances Tsao, Ming-Sound Arnold, Susanne M. Haura, Eric B. Bolca, Ciprian Holcatova, Ivana Janout, Vladimir Kontic, Milica Lissowska, Jolanta Mukeria, Anush Ognjanovic, Simona Orlowski, Tadeusz M. Scelo, Ghislaine Swiatkowska, Beata Zaridze, David Bakke, Per Skaug, Vidar Zienolddiny, Shanbeh Duell, Eric J. Butler, Lesley M. Koh, Woon-Puay Gao, Yu-Tang Houlston, Richard McLaughlin, John Stevens, Victoria Nickle, David C. Obeidat, Ma’en Timens, Wim Zhu, Bin Song, Lei Artigas, María Soler Tobin, Martin D. Wain, Louise V. Gu, Fangyi Byun, Jinyoung Kamal, Ahsan Zhu, Dakai Tyndale, Rachel F. Wei, Wei-Qi Chanock, Stephen Brennan, Paul Amos, Christopher I. Nat Commun Article Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer. Nature Publishing Group UK 2018-08-13 /pmc/articles/PMC6089967/ /pubmed/30104567 http://dx.doi.org/10.1038/s41467-018-05074-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ji, Xuemei
Bossé, Yohan
Landi, Maria Teresa
Gui, Jiang
Xiao, Xiangjun
Qian, David
Joubert, Philippe
Lamontagne, Maxime
Li, Yafang
Gorlov, Ivan
de Biasi, Mariella
Han, Younghun
Gorlova, Olga
Hung, Rayjean J.
Wu, Xifeng
McKay, James
Zong, Xuchen
Carreras-Torres, Robert
Christiani, David C.
Caporaso, Neil
Johansson, Mattias
Liu, Geoffrey
Bojesen, Stig E.
Le Marchand, Loic
Albanes, Demetrios
Bickeböller, Heike
Aldrich, Melinda C.
Bush, William S.
Tardon, Adonina
Rennert, Gad
Chen, Chu
Teare, M. Dawn
Field, John K.
Kiemeney, Lambertus A.
Lazarus, Philip
Haugen, Aage
Lam, Stephen
Schabath, Matthew B.
Andrew, Angeline S.
Shen, Hongbing
Hong, Yun-Chul
Yuan, Jian-Min
Bertazzi, Pier A.
Pesatori, Angela C.
Ye, Yuanqing
Diao, Nancy
Su, Li
Zhang, Ruyang
Brhane, Yonathan
Leighl, Natasha
Johansen, Jakob S.
Mellemgaard, Anders
Saliba, Walid
Haiman, Christopher
Wilkens, Lynne
Fernandez-Somoano, Ana
Fernandez-Tardon, Guillermo
van der Heijden, Erik H. F. M.
Kim, Jin Hee
Dai, Juncheng
Hu, Zhibin
Davies, Michael P. A.
Marcus, Michael W.
Brunnström, Hans
Manjer, Jonas
Melander, Olle
Muller, David C.
Overvad, Kim
Trichopoulou, Antonia
Tumino, Rosario
Doherty, Jennifer
Goodman, Gary E.
Cox, Angela
Taylor, Fiona
Woll, Penella
Brüske, Irene
Manz, Judith
Muley, Thomas
Risch, Angela
Rosenberger, Albert
Grankvist, Kjell
Johansson, Mikael
Shepherd, Frances
Tsao, Ming-Sound
Arnold, Susanne M.
Haura, Eric B.
Bolca, Ciprian
Holcatova, Ivana
Janout, Vladimir
Kontic, Milica
Lissowska, Jolanta
Mukeria, Anush
Ognjanovic, Simona
Orlowski, Tadeusz M.
Scelo, Ghislaine
Swiatkowska, Beata
Zaridze, David
Bakke, Per
Skaug, Vidar
Zienolddiny, Shanbeh
Duell, Eric J.
Butler, Lesley M.
Koh, Woon-Puay
Gao, Yu-Tang
Houlston, Richard
McLaughlin, John
Stevens, Victoria
Nickle, David C.
Obeidat, Ma’en
Timens, Wim
Zhu, Bin
Song, Lei
Artigas, María Soler
Tobin, Martin D.
Wain, Louise V.
Gu, Fangyi
Byun, Jinyoung
Kamal, Ahsan
Zhu, Dakai
Tyndale, Rachel F.
Wei, Wei-Qi
Chanock, Stephen
Brennan, Paul
Amos, Christopher I.
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_full Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_fullStr Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_full_unstemmed Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_short Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_sort identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967/
https://www.ncbi.nlm.nih.gov/pubmed/30104567
http://dx.doi.org/10.1038/s41467-018-05074-y
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AT rischangela identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT rosenbergeralbert identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT grankvistkjell identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT johanssonmikael identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT shepherdfrances identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT tsaomingsound identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT arnoldsusannem identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT hauraericb identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT bolcaciprian identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT holcatovaivana identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT janoutvladimir identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT konticmilica identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT lissowskajolanta identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT mukeriaanush identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT ognjanovicsimona identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT orlowskitadeuszm identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT sceloghislaine identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT swiatkowskabeata identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT zaridzedavid identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT bakkeper identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT skaugvidar identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT zienolddinyshanbeh identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT duellericj identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT butlerlesleym identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT kohwoonpuay identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT gaoyutang identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT houlstonrichard identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT mclaughlinjohn identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT stevensvictoria identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT nickledavidc identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT obeidatmaen identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT timenswim identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT zhubin identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT songlei identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT artigasmariasoler identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT tobinmartind identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT wainlouisev identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT gufangyi identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT byunjinyoung identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT kamalahsan identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT zhudakai identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT tyndalerachelf identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT weiweiqi identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT chanockstephen identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT brennanpaul identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT amoschristopheri identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk