Cargando…
Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
Eukaryotic voltage-gated sodium channels play key roles in physiology and are targets for many toxins and medically important drugs. Physiology, pharmacology, and general architecture of the channels has long been the subject of intensive research in academia and industry. In particular, animal toxi...
Autores principales: | Tikhonov, Denis B., Zhorov, Boris S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090064/ https://www.ncbi.nlm.nih.gov/pubmed/30131702 http://dx.doi.org/10.3389/fphar.2018.00880 |
Ejemplares similares
-
Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4
por: Korkosh, Viacheslav S., et al.
Publicado: (2014) -
Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants
por: Tikhonov, Denis B., et al.
Publicado: (2017) -
Intersegment Contacts of Potentially Damaging Variants of Cardiac Sodium Channel
por: Korkosh, Vyacheslav S., et al.
Publicado: (2021) -
P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models
por: Tikhonov, Denis B., et al.
Publicado: (2022) -
Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs
por: Tikhonov, Denis B., et al.
Publicado: (2021)