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ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells

Neuroblastoma is one of the most common and deadly childhood cancers. Neuroblastoma arises from transformed cells of the neural crest lineage. Outcomes of the disease vary greatly, ranging from spontaneous regression to aggressive metastases. While this variability may reflect the inherent migratory...

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Autores principales: Gonzalez Malagon, Sandra G, Liu, Karen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090488/
https://www.ncbi.nlm.nih.gov/pubmed/30127638
http://dx.doi.org/10.1177/1179069518792499
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author Gonzalez Malagon, Sandra G
Liu, Karen J
author_facet Gonzalez Malagon, Sandra G
Liu, Karen J
author_sort Gonzalez Malagon, Sandra G
collection PubMed
description Neuroblastoma is one of the most common and deadly childhood cancers. Neuroblastoma arises from transformed cells of the neural crest lineage. Outcomes of the disease vary greatly, ranging from spontaneous regression to aggressive metastases. While this variability may reflect the inherent migratory capabilities and multipotency of neural crest cells, there have been few direct comparisons between neuroblastoma and embryonic neural crest cells, in part because of the limited in vivo accessibility of the mammalian neural crest lineage. Our recent studies demonstrate a novel link between anaplastic lymphoma kinase (ALK) and glycogen synthase kinase 3 (GSK3). Our work suggests that ALK-dependent regulation of GSK3 via tyrosine phosphorylation may alter the substrate specificity of GSK3, thus regulating cytoskeletal dynamics in migrating neural crest cells.
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spelling pubmed-60904882018-08-20 ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells Gonzalez Malagon, Sandra G Liu, Karen J J Exp Neurosci Commentary Neuroblastoma is one of the most common and deadly childhood cancers. Neuroblastoma arises from transformed cells of the neural crest lineage. Outcomes of the disease vary greatly, ranging from spontaneous regression to aggressive metastases. While this variability may reflect the inherent migratory capabilities and multipotency of neural crest cells, there have been few direct comparisons between neuroblastoma and embryonic neural crest cells, in part because of the limited in vivo accessibility of the mammalian neural crest lineage. Our recent studies demonstrate a novel link between anaplastic lymphoma kinase (ALK) and glycogen synthase kinase 3 (GSK3). Our work suggests that ALK-dependent regulation of GSK3 via tyrosine phosphorylation may alter the substrate specificity of GSK3, thus regulating cytoskeletal dynamics in migrating neural crest cells. SAGE Publications 2018-08-13 /pmc/articles/PMC6090488/ /pubmed/30127638 http://dx.doi.org/10.1177/1179069518792499 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Gonzalez Malagon, Sandra G
Liu, Karen J
ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells
title ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells
title_full ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells
title_fullStr ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells
title_full_unstemmed ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells
title_short ALK and GSK3: Shared Features of Neuroblastoma and Neural Crest Cells
title_sort alk and gsk3: shared features of neuroblastoma and neural crest cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090488/
https://www.ncbi.nlm.nih.gov/pubmed/30127638
http://dx.doi.org/10.1177/1179069518792499
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