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Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance...

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Detalles Bibliográficos
Autores principales:	Arasada, Rajeswara Rao, Shilo, Konstantin, Yamada, Tadaaki, Zhang, Jianying, Yano, Seiji, Ghanem, Rashelle, Wang, Walter, Takeuchi, Shinji, Fukuda, Koji, Katakami, Nobuyuki, Tomii, Keisuke, Ogushi, Fumitaka, Nishioka, Yasuhiko, Talabere, Tiffany, Misra, Shrilekha, Duan, Wenrui, Fadda, Paolo, Rahman, Mohammad A., Nana-Sinkam, Patrick, Evans, Jason, Amann, Joseph, Tchekneva, Elena E., Dikov, Mikhail M., Carbone, David P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090531/ https://www.ncbi.nlm.nih.gov/pubmed/30097569 http://dx.doi.org/10.1038/s41467-018-05626-2

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