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Clinical significance of serum soluble B7-H3 in patients with osteosarcoma
BACKGROUND: Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance in osteosarcoma (OS) are not well known. In this present study, we investigated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090643/ https://www.ncbi.nlm.nih.gov/pubmed/30123093 http://dx.doi.org/10.1186/s12935-018-0614-z |
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author | Wang, Ling Kang, Fu-biao Zhang, Guo-chuan Wang, Juan Xie, Ming-fang Zhang, Ying-ze |
author_facet | Wang, Ling Kang, Fu-biao Zhang, Guo-chuan Wang, Juan Xie, Ming-fang Zhang, Ying-ze |
author_sort | Wang, Ling |
collection | PubMed |
description | BACKGROUND: Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance in osteosarcoma (OS) are not well known. In this present study, we investigated whether sB7-H3 levels in serum could be as a tool for differential diagnosis of OS patients. METHODS: Peripheral blood samples from healthy controls, benign bone tumors, and OS patients were collected. Levels of sB7-H3 in serum samples were measured by enzyme-linked immunosorbent assays. The correlation between OS-derived sB7-H3 and clinical features was analyzed, and prognostic significance of the sB7-H3 concentrations and tumor expressions of the biomarkers was then evaluated. RESULTS: sB7-H3 concentrations were significantly increased in patients with OS than in osteochondroma patients, bone fibrous dysplasia patients and healthy people (p < 0.05, respectively). Using 60.94 ng/mL as a cutoff value, the sensitivity and specificity of sB7-H3 was to differentiate between OS patients and other bone benign tumor patients were 75.7% and 83.8%, respectively. In addition, upregulated serum sB7-H3 in patients with OS associated with tumor differentiation, tumor stage, and metastasis status (p < 0.05, respectively). The area under the curve value for sB7-H3 (0.868) was markedly higher than those for ALP (0.713) and CA125 (0.789) for differentiating between OS patients and other begin bone tumor patients. CONCLUSIONS: We demonstrated that enhanced sB7-H3 levels correlated with the clinical characteristics of OS patients, and B7-H3 might be a potential biomarker and associated with the pathogenesis of OS. |
format | Online Article Text |
id | pubmed-6090643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60906432018-08-17 Clinical significance of serum soluble B7-H3 in patients with osteosarcoma Wang, Ling Kang, Fu-biao Zhang, Guo-chuan Wang, Juan Xie, Ming-fang Zhang, Ying-ze Cancer Cell Int Primary Research BACKGROUND: Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance in osteosarcoma (OS) are not well known. In this present study, we investigated whether sB7-H3 levels in serum could be as a tool for differential diagnosis of OS patients. METHODS: Peripheral blood samples from healthy controls, benign bone tumors, and OS patients were collected. Levels of sB7-H3 in serum samples were measured by enzyme-linked immunosorbent assays. The correlation between OS-derived sB7-H3 and clinical features was analyzed, and prognostic significance of the sB7-H3 concentrations and tumor expressions of the biomarkers was then evaluated. RESULTS: sB7-H3 concentrations were significantly increased in patients with OS than in osteochondroma patients, bone fibrous dysplasia patients and healthy people (p < 0.05, respectively). Using 60.94 ng/mL as a cutoff value, the sensitivity and specificity of sB7-H3 was to differentiate between OS patients and other bone benign tumor patients were 75.7% and 83.8%, respectively. In addition, upregulated serum sB7-H3 in patients with OS associated with tumor differentiation, tumor stage, and metastasis status (p < 0.05, respectively). The area under the curve value for sB7-H3 (0.868) was markedly higher than those for ALP (0.713) and CA125 (0.789) for differentiating between OS patients and other begin bone tumor patients. CONCLUSIONS: We demonstrated that enhanced sB7-H3 levels correlated with the clinical characteristics of OS patients, and B7-H3 might be a potential biomarker and associated with the pathogenesis of OS. BioMed Central 2018-08-13 /pmc/articles/PMC6090643/ /pubmed/30123093 http://dx.doi.org/10.1186/s12935-018-0614-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Primary Research Wang, Ling Kang, Fu-biao Zhang, Guo-chuan Wang, Juan Xie, Ming-fang Zhang, Ying-ze Clinical significance of serum soluble B7-H3 in patients with osteosarcoma |
title | Clinical significance of serum soluble B7-H3 in patients with osteosarcoma |
title_full | Clinical significance of serum soluble B7-H3 in patients with osteosarcoma |
title_fullStr | Clinical significance of serum soluble B7-H3 in patients with osteosarcoma |
title_full_unstemmed | Clinical significance of serum soluble B7-H3 in patients with osteosarcoma |
title_short | Clinical significance of serum soluble B7-H3 in patients with osteosarcoma |
title_sort | clinical significance of serum soluble b7-h3 in patients with osteosarcoma |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090643/ https://www.ncbi.nlm.nih.gov/pubmed/30123093 http://dx.doi.org/10.1186/s12935-018-0614-z |
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