Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry

BACKGROUND: Primaquine (PQ), an 8-aminoquinoline, is the only drug approved by the United States Food and Drug Administration for radical cure and prevention of relapse in Plasmodium vivax infections. Knowledge of the metabolism of PQ is critical for understanding the therapeutic efficacy and hemoly...

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Detalles Bibliográficos
Autores principales: Avula, Bharathi, Tekwani, Babu L., Chaurasiya, Narayan D., Fasinu, Pius, Dhammika Nanayakkara, N. P., Bhandara Herath, H. M. T., Wang, Yan-Hong, Bae, Ji-Yeong, Khan, Shabana I., Elsohly, Mahmoud A., McChesney, James D., Zimmerman, Peter A., Khan, Ikhlas A., Walker, Larry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090659/
https://www.ncbi.nlm.nih.gov/pubmed/30103751
http://dx.doi.org/10.1186/s12936-018-2433-z

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