Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

BACKGROUND: The first pathology observed in Parkinson’s disease (PD) is ‘dying back’ of striatal dopaminergic (DA) terminals. Connexin (Cx)30, an astrocytic gap junction protein, is upregulated in the striatum in PD, but its roles in neurodegeneration remain elusive. We investigated Cx30 function in...

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Detalles Bibliográficos
Autores principales: Fujita, Atsushi, Yamaguchi, Hiroo, Yamasaki, Ryo, Cui, Yiwen, Matsuoka, Yuta, Yamada, Ken-ichi, Kira, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090688/
https://www.ncbi.nlm.nih.gov/pubmed/30103794
http://dx.doi.org/10.1186/s12974-018-1251-0

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