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Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis

The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized. In the current review, we focus on the contribution of s...

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Detalles Bibliográficos
Autores principales: Atanasova, Kalina R., Reznikov, Leah R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090699/
https://www.ncbi.nlm.nih.gov/pubmed/30081920
http://dx.doi.org/10.1186/s12931-018-0846-4
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author Atanasova, Kalina R.
Reznikov, Leah R.
author_facet Atanasova, Kalina R.
Reznikov, Leah R.
author_sort Atanasova, Kalina R.
collection PubMed
description The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized. In the current review, we focus on the contribution of select neuropeptides in three distinct airway diseases: asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. We present data on some well-studied neuropeptides, as well as call attention to a few that have not received much consideration. Because mucus hypersecretion and mucus obstruction are common features of many airway diseases, we place special emphasis on the contribution of neuropeptides to mucus secretion. Finally, we highlight evidence implicating involvement of neuropeptides in mucus phenotypes in asthma, COPD and cystic fibrosis, as well as bring to light knowledge that is still lacking in the field.
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spelling pubmed-60906992018-08-17 Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis Atanasova, Kalina R. Reznikov, Leah R. Respir Res Review The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized. In the current review, we focus on the contribution of select neuropeptides in three distinct airway diseases: asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. We present data on some well-studied neuropeptides, as well as call attention to a few that have not received much consideration. Because mucus hypersecretion and mucus obstruction are common features of many airway diseases, we place special emphasis on the contribution of neuropeptides to mucus secretion. Finally, we highlight evidence implicating involvement of neuropeptides in mucus phenotypes in asthma, COPD and cystic fibrosis, as well as bring to light knowledge that is still lacking in the field. BioMed Central 2018-08-06 2018 /pmc/articles/PMC6090699/ /pubmed/30081920 http://dx.doi.org/10.1186/s12931-018-0846-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Atanasova, Kalina R.
Reznikov, Leah R.
Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
title Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
title_full Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
title_fullStr Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
title_full_unstemmed Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
title_short Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
title_sort neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090699/
https://www.ncbi.nlm.nih.gov/pubmed/30081920
http://dx.doi.org/10.1186/s12931-018-0846-4
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