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Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors

OBJECTIVE: Fine needle aspiration biospy (FNAB) is a simple, cost effective procedure, which can be carried out in the out-patient department. The objective of our study was to determine the diagnostic accuracy of fine needle aspiration biopsy in small round cell tumors of childhood, keeping histopa...

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Autores principales: Asim, Marrium, Mudassir, Ghazala, Hashmi, Atif Ali, Abid, Mariam, Sheikh, Ahmareen Khalid, Naveed, Hania, Habib, Maryam, Edhi, Muhammad Muzzammil, Khan, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090781/
https://www.ncbi.nlm.nih.gov/pubmed/30103805
http://dx.doi.org/10.1186/s13104-018-3678-x
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author Asim, Marrium
Mudassir, Ghazala
Hashmi, Atif Ali
Abid, Mariam
Sheikh, Ahmareen Khalid
Naveed, Hania
Habib, Maryam
Edhi, Muhammad Muzzammil
Khan, Amir
author_facet Asim, Marrium
Mudassir, Ghazala
Hashmi, Atif Ali
Abid, Mariam
Sheikh, Ahmareen Khalid
Naveed, Hania
Habib, Maryam
Edhi, Muhammad Muzzammil
Khan, Amir
author_sort Asim, Marrium
collection PubMed
description OBJECTIVE: Fine needle aspiration biospy (FNAB) is a simple, cost effective procedure, which can be carried out in the out-patient department. The objective of our study was to determine the diagnostic accuracy of fine needle aspiration biopsy in small round cell tumors of childhood, keeping histopathology as the gold standard. RESULTS: Out of these 50 cases, 35 (70%) were small round cell tumors and 15 (30%) cases of other childhood malignancies and certain reactive conditions. In our study, the most common malignant small round cell tumor (SRCT) on histopathology was Wilms tumor (10 cases) followed by non Hodgkin lymphoma (9 cases). FNAB results were correlated with the histological findings and the diagnostic accuracy of SRCT came out to be 98%. The sensitivity and specificity of FNAB in diagnosing SRCT was 97% and 100% respectively. FNAB was found to be a very useful technique in the initial evaluation of any palpable lesion of childhood. Although the small round cell tumors appear cytologically similar, in the hands of experienced cytopathologists, the subtle morphological features can help towards the final diagnosis. In addition, clinical and radiological findings are invaluable assets, which help to reach the final diagnosis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3678-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-60907812018-08-17 Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors Asim, Marrium Mudassir, Ghazala Hashmi, Atif Ali Abid, Mariam Sheikh, Ahmareen Khalid Naveed, Hania Habib, Maryam Edhi, Muhammad Muzzammil Khan, Amir BMC Res Notes Research Note OBJECTIVE: Fine needle aspiration biospy (FNAB) is a simple, cost effective procedure, which can be carried out in the out-patient department. The objective of our study was to determine the diagnostic accuracy of fine needle aspiration biopsy in small round cell tumors of childhood, keeping histopathology as the gold standard. RESULTS: Out of these 50 cases, 35 (70%) were small round cell tumors and 15 (30%) cases of other childhood malignancies and certain reactive conditions. In our study, the most common malignant small round cell tumor (SRCT) on histopathology was Wilms tumor (10 cases) followed by non Hodgkin lymphoma (9 cases). FNAB results were correlated with the histological findings and the diagnostic accuracy of SRCT came out to be 98%. The sensitivity and specificity of FNAB in diagnosing SRCT was 97% and 100% respectively. FNAB was found to be a very useful technique in the initial evaluation of any palpable lesion of childhood. Although the small round cell tumors appear cytologically similar, in the hands of experienced cytopathologists, the subtle morphological features can help towards the final diagnosis. In addition, clinical and radiological findings are invaluable assets, which help to reach the final diagnosis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3678-x) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-13 /pmc/articles/PMC6090781/ /pubmed/30103805 http://dx.doi.org/10.1186/s13104-018-3678-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Asim, Marrium
Mudassir, Ghazala
Hashmi, Atif Ali
Abid, Mariam
Sheikh, Ahmareen Khalid
Naveed, Hania
Habib, Maryam
Edhi, Muhammad Muzzammil
Khan, Amir
Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors
title Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors
title_full Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors
title_fullStr Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors
title_full_unstemmed Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors
title_short Diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors
title_sort diagnostic accuracy of fine needle aspiration biopsy in pediatric small round cell tumors
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090781/
https://www.ncbi.nlm.nih.gov/pubmed/30103805
http://dx.doi.org/10.1186/s13104-018-3678-x
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