Targeting the IDO1 pathway in cancer: from bench to bedside

Indoleamine 2, 3-dioxygenases (IDO1 and IDO2) and tryptophan 2, 3-dioxygenase (TDO) are tryptophan catabolic enzymes that catalyze the conversion of tryptophan into kynurenine. The depletion of tryptophan and the increase in kynurenine exert important immunosuppressive functions by activating T regu...

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Detalles Bibliográficos
Autores principales: Liu, Ming, Wang, Xu, Wang, Lei, Ma, Xiaodong, Gong, Zhaojian, Zhang, Shanshan, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090955/
https://www.ncbi.nlm.nih.gov/pubmed/30068361
http://dx.doi.org/10.1186/s13045-018-0644-y

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