Pharmacologically upregulated carcinoembryonic antigen-expression enhances the cytolytic activity of genetically-modified chimeric antigen receptor NK-92MI against colorectal cancer cells

BACKGROUND: The natural killer cell line, NK-92MI, is cytotoxic against various types of cancer. The aim of this study was to develop chimeric antigen receptor-modified (CAR) NK-92MI cells targeting carcinoembryonic antigen-expressing (CEA) tumours and increase killing efficacy by pharmacologically...

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Detalles Bibliográficos
Autores principales: Shiozawa, Masayuki, Chang, Chuan-Hsin, Huang, Yi-Chun, Chen, Yi-Ching, Chi, Mau-Shin, Hao, Hsu-Chao, Chang, Yue-Cune, Takeda, Satoru, Chi, Kwan-Hwa, Wang, Yu-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091054/
https://www.ncbi.nlm.nih.gov/pubmed/30075754
http://dx.doi.org/10.1186/s12865-018-0262-z

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