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2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways

BACKGROUND: The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated protein kinase (MAPK) signaling. Endocannabinoid 2-arachidonyl glycerol (2-AG) has been described to serve as an endogenous medi...

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Detalles Bibliográficos
Autores principales:	Wang, Shenghong, Zhang, Hua, Geng, Bin, Xie, Qiqi, Li, Wenzhou, Deng, Yajun, Shi, Weidong, Pan, Yunyan, Kang, Xuewen, Wang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091076/ https://www.ncbi.nlm.nih.gov/pubmed/30075820 http://dx.doi.org/10.1186/s12974-018-1254-x

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