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Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

BACKGROUND: Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegrin and me...

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Detalles Bibliográficos
Autores principales:	Zhu, Xinjian, Li, Xiaolin, Zhu, Mengyi, Xu, Kangni, Yang, Li, Han, Bing, Huang, Rongrong, Zhang, Aifeng, Yao, Honghong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091106/ https://www.ncbi.nlm.nih.gov/pubmed/30075790 http://dx.doi.org/10.1186/s12974-018-1260-z

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