Preclinical Evaluation of [(18)F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

The bile acid analogue [ (18) F]LCATD (LithoCholic Acid Triazole Derivative) is transported in vitro by hepatic uptake transporters such as OATP1B1 and NTCP and efflux transporter BSEP. In this in vivo “proof of principle” study, we tested if [ (18) F]LCATD may be used to evaluate drug-drug interact...

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Detalles Bibliográficos
Autores principales: Testa, Andrea, Dall'Angelo, Sergio, Mingarelli, Marco, Augello, Andrea, Schweiger, Lutz, Welch, Andrew, Elmore, Charles S., Dawson, Dana, Sharma, Pradeep, Zanda, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091370/
https://www.ncbi.nlm.nih.gov/pubmed/30154685
http://dx.doi.org/10.1155/2018/3064751

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