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Who's on base? Revealing the catalytic mechanism of inverting family 6 glycoside hydrolases

In several important classes of inverting carbohydrate-active enzymes, the identity of the catalytic base remains elusive, including in family 6 Glycoside Hydrolase (GH6) enzymes, which are key components of cellulase cocktails for cellulose depolymerization. Despite many structural and kinetic stud...

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Detalles Bibliográficos
Autores principales: Mayes, Heather B., Knott, Brandon C., Crowley, Michael F., Broadbelt, Linda J., Ståhlberg, Jerry, Beckham, Gregg T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091422/
https://www.ncbi.nlm.nih.gov/pubmed/30155195
http://dx.doi.org/10.1039/c6sc00571c